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This study aims to explore the effect of ciprofol on the postoperative cognitive function of inpatients undergoing gastrointestinal endoscopy examination, to compare the anesthetic effects and differences in adverse reactions of propofol and ciprofol in gastrointestinal endoscopy , to compare the incidence of postoperative cognitive decline in patients undergoing gastrointestinal endoscopy examination between propofol and coprofol, and to optimize the anesthesia medication regimen for patients undergoing gastrointestinal endoscopy examination.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental group (ciprofol) | Experimental | patients in the Ciprofol group will use ciprofol to complete the painless gastroscopy and colonoscopy treatment. |
|
| Control group (propofol) | Active Comparator | patients in the propofol group will use propofol to complete the painless gastroscopy and colonoscopy treatment. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ciprofol group | Drug | patients in the Ciprofol group will use ciprofol to complete the painless gastroscopy and colonoscopy treatment. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The difference in the incidence of cognitive function decline between ciprofol and propofol in patients undergoing painless gastroscopy and colonoscopy treatment | From the time the patient was enrolled in the study to 24 hours after the treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Intraoperative and postoperative adverse events | From the time the patient enters the operating room to 24 hours after the treatment | |
| Blood Pressure (mmHg) | Non-invasive BP measured by cuff after entry and intermittently during surgery. Hypotension: SBP decrease >30% from baseline; Hypertension: SBP increase >30% from baseline. |
| Measure | Description | Time Frame |
|---|---|---|
| The dosage of propofol/ciprofol used | The dosage of drugs used during this period from anesthesia induction to the end of anesthesia (perioperative period) (approximately 25 - 60 minutes) | |
| The patient's stay time in the PACU(Post-Anesthesia Care Unit) | The period from when the patients enter the PACU until they leave the PACU |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Guangyou Duan | The Second Affiliated Hospital of Chongqing Medical University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Second Affiliated Hospital Of Chongqing Medical University | Chongqing | Chongqing Municipality | 400010 | China |
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| ID | Term |
|---|---|
| D000079690 | Postoperative Cognitive Complications |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D060825 | Cognitive Dysfunction |
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| Propofol group | Drug | patients in the propofol group will use propofol to complete the painless gastroscopy and colonoscopy treatment. |
|
| From entering the operating room to leaving it (before anesthesia, after induction, and 5 minutes、10 minutes 、20 minutes 、30 minutes 、40 minutes、50 minutes、60 minutes after the operation began) |
| Heart Rate (beats/min) | Read from monitor. Bradycardia: <50 bpm or decrease ≥25% from baseline; Tachycardia: >100 bpm or increase ≥25% from baseline. | From entering the operating room to leaving it (before anesthesia, after induction, and 5 minutes、10 minutes 、20 minutes 、30 minutes 、40 minutes、50 minutes、60 minutes after the operation began) |
| Respiratory Rate (breaths/min) | Read from monitor or counted over 1 min. Respiratory depression: <8 breaths/min lasting >30 sec. | From entering the operating room to leaving it (before anesthesia, after induction, and 5 minutes、10 minutes 、20 minutes 、30 minutes 、40 minutes、50 minutes、60 minutes after the operation began) |
| Oxygen Saturation (Pulse Oximetry) | Read from monitor. Hypoxemia: SpO2 <90% lasting >15 sec. | From entering the operating room to leaving it (before anesthesia, after induction, and 5 minutes、10 minutes 、20 minutes 、30 minutes 、40 minutes、50 minutes、60 minutes after the operation began) |
| up to 24 hours |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |