Effect of Ciprofol Injection on Postoperative Cognitive Function

A Controlled Study on the Impact of Ciprofol Injection on Postoperative Cognitive Function and Its Mechanism

This study aims to explore the effect of ciprofol on the postoperative cognitive function of inpatients undergoing gastrointestinal endoscopy examination, to compare the anesthetic effects and differences in adverse reactions of propofol and ciprofol in gastrointestinal endoscopy , to compare the incidence of postoperative cognitive decline in patients undergoing gastrointestinal endoscopy examination between propofol and coprofol, and to optimize the anesthesia medication regimen for patients undergoing gastrointestinal endoscopy examination.

Inclusion Criteria:

1. Age: 18-65 years old, ASA grade I-Ⅲ, BMI index: 18.5-30 kg/m ²
2. Patients who plan to undergo gastroscopy or colonoscopy in our hospital
3. The preoperative assessment of the MOCA scale in patients scheduled for elective surgery indicated normal cognitive function
4. dextromanuality
5. Voluntarily participate in this study and sign the informed consent form

Exclusion Criteria:

1. Pregnant or lactating women
2. Patients who have had cardiovascular and cerebrovascular accidents in the past
3. Patients with severe diseases of the cardiovascular system, respiratory system and liver and kidney system
4. Patients with obstructive sleep apnea syndrome
5. Patients with concurrent neurological or mental system diseases, or those with incomplete intellectual development
6. Patients allergic to ciprofol or propofol drugs
7. Patients with braking, visual/auditory impairments
8. Patients with psychotropic drug addiction or alcohol dependence
9. Patients who themselves or their attending physicians refused to participate in the study