Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Ciprofol, a novel intravenous general anesthetic with a chemical structure akin to propofol, boasts significantly enhanced potency. It offers a rapid onset, reduced incidence of injection pain, and minor impact on the cardiovascular system. However, clinical research regarding ciprofol's use for anesthesia induction in cardiac surgery remains limited.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental: ciprofol | Experimental |
| |
| Placebo Comparator: propofol | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Drug: ciprofol injection | Drug | Patients in ciprofol group 0.3 mg/kg ciprofol for induction of anesthesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mean arterial pressure | an average blood pressure in an individual during a single cardiac cycle | 1 second before induction of anesthesia (T1) |
| Mean arterial pressure | an average blood pressure in an individual during a single cardiac cycle | 1 second before tracheal intubation (T2) |
| Mean arterial pressure | an average blood pressure in an individual during a single cardiac cycle | 1 minute after tracheal intubation (T3) |
| Mean arterial pressure | an average blood pressure in an individual during a single cardiac cycle | 5 minutes after tracheal intubation (T4) |
| Heart beats | the number of times each minute that heart beats | 1 second before induction of anesthesia (T1) |
| Heart beats | the number of times each minute that heart beats | 1 second before tracheal intubation (T2) |
| Heart beats | the number of times each minute that heart beats | 1 minute after tracheal intubation (T3) |
| Heart beats | the number of times each minute that heart beats |
| Measure | Description | Time Frame |
|---|---|---|
| Oxygenation index | a calculation used in intensive care medicine to measure the fraction of inspired oxygen (FiO2) and its usage within the body. | 1 second before induction of anesthesia (T1) |
| Oxygenation index |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai East Hospital of Tongji University | Recruiting | Shanghai | Shanghai Municipality | 200120 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39533186 | Derived | Yu L, Liu X, Zhao X, Shan X, Bischof E, Lu HH. Ciprofol versus propofol for anesthesia induction in cardiac surgery: a randomized double-blind controlled clinical trial. BMC Anesthesiol. 2024 Nov 12;24(1):412. doi: 10.1186/s12871-024-02795-0. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| C000730795 | (2-(1R)-1-cyclopropyl)ethyl-6-isopropyl-phenol |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| 5 minutes after tracheal intubation (T4) |
a calculation used in intensive care medicine to measure the fraction of inspired oxygen (FiO2) and its usage within the body.
| 10 minutes after tracheal intubation (T5) |
| Injection pain | Pain at the injection site when injecting the drugļ¼Evaluation with Visual Analogue Scaleļ¼ | During procedure (When injecting the drug, ask the subject if the injection site is painful) |