Patients with essential hypertension in cold regions who met the inclusion criteria were prospectively recruited and divided into an exercise exposure group and a non-exercise control group based on their willingness to accept and adhere to the exercise protocol developed for this study, with a follow-up period of 16 weeks. At baseline and the end of follow-up, we measured the expression of core thermosensitive targets, blood pressure (BP), heart rate variability (HRV), as well as the levels of sympathetic neurotransmitters and indicators of the renin-angiotensin-aldosterone system (RAAS), and compared the changes in these indicators between the two groups.

Systolic blood pressure, unit: mmHg Diastolic blood pressure, unit: mmHg Mean arterial pressure, unit: mmHg

Low Frequency，Unit: nu High Frequency ，Unit: nu Low Frequency / High Frequency ratio Root Mean Square of Successive Differences，Unit: ms Percentage of successive NN intervals differing by more than 50 ms，Unit: % Standard Deviation of all Normal-to-Normal RR intervals，Unit: ms

Epinephrine, unit: ng/L Norepinephrine, unit: ng/L

Unit: relative expression level