Impact of Aerobic Exercise Training on Sympathetic Vasoconstriction and Vascular Function in Essential Hypertension

Impact of Aerobic Exercise Training on Sympathetically Mediated Vasoconstriction and Vascular Function in Individuals With Essential Hypertension (IMPROVEH)

Sympathetic nervous activity plays an important role in the development of hypertension and studies have shown that the pannexin-1 channel is involved in the signalling of the sympathetic activity to the vascular bed. The main project aim is to investigate the effects of 10 weeks of high intensity training on the effect of the sympathetic nervous activity on vascular function in individuals with essential hypertension. A secondary aim is to assess the role of essential hypertension and physical activity on vascular endothelial function,

Inclusion Criteria:

• Sedentary men and women age 35 - 65 years
• Resting blood pressure >140/90 mmHg or Resting blood pressure <140/90 mmHg
• Essential hypertension
• Non or exclusively antihypertensive medication

Exclusion Criteria:

• Hypertensive condition other than essential hypertension
• Other chronical diseases
• Smoking
• Excess alcohol intake or drug abuse