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| Name | Class |
|---|---|
| Zhongda Hospital | OTHER |
| First Affiliated Hospital of Chongqing Medical University | OTHER |
| Shenzhen Mindray Bio-Medical Electronics Co., Ltd | UNKNOWN |
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This project plans to employ a multi-center retrospective and prospective cohort study design. It aims to collect data on ventilator support strategies, duration of invasive mechanical ventilation, incidence of ventilator dependence, high-risk factors for ventilator dependence, and in-hospital mortality rates among different chronic disease populations in the ICU. This will involve combining unstructured data with real-time bedside multi-dimensional high-frequency data (including dynamic changes in data volume, respiratory mechanics, diaphragm ultrasound, EIT, diaphragm electrical activity, and other monitoring parameters) to construct digital phenotypes for chronic disease patients with ventilator dependence and identify high-risk factors for ventilator dependence in this population.
Specifically, the research will:
Utilize an integrated modular intelligent respiratory monitoring system, previously developed by the project team, to achieve dynamic monitoring of multi-dimensional indicators.
Systematically collect dynamic clinical characteristics of mechanical ventilation dependence in chronic disease populations through retrospective and prospective cohort studies, and employ multivariate statistical analysis, machine learning, and other techniques to identify no fewer than 5-6 high-risk factors for ventilator dependence in chronic disease patients.
Establish a data ecosystem suitable for chronic disease patients undergoing mechanical ventilation, build a multi-dimensional high-frequency data platform for chronic ventilator-dependent populations, map the full cycle from intubation to mechanical ventilation support, weaning, and extubation, and construct multidimensional digital phenotypes for high-risk chronic disease patients with ventilator dependence.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients in the Multicenter Retrospective Cohort | |||
| Patients in the Multi-Center Prospective Cohort |
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| Measure | Description | Time Frame |
|---|---|---|
| Proportion of ventilator dependence（mechanical ventilation time≥7 days） in chronic disease patients receiving invasive mechanical ventilation | the proportion of patients who achieve sustained liberation from invasive mechanical ventilation within 7 days of the initial intubation. | From enrollment to 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of chronic disease patients still receiving IPPV at 14/21 days after mechanical ventilation | the proportion of patients who achieve sustained liberation from invasive mechanical ventilation within 14 and 21 days of the initial intubation. | 21 days |
| Success rate of the first Spontaneous Breathing Trial (SBT) in chronic disease patients |
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Inclusion Criteria:
Exclusion Criteria:
Biological Sex
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Chronic Disease Patients with invasive mechanical ventilation ≥48 hours
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| Name | Affiliation | Role |
|---|---|---|
| Xu Huang, MD | Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital | Beijing | Beijing Municipality | 100029 | China |
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| ID | Term |
|---|---|
| D002908 | Chronic Disease |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| during hospitalization，assessed up to 28 days |
| Time to first extubation in chronic disease patients | during hospitalization，assessed up to 28 days |
| Proportion of first extubation failure in chronic disease patients | during hospitalization，assessed up to 28 days |
| High-risk factors for first extubation failure in chronic disease patients | during hospitalization，assessed up to 28 days |
| ICU mortality rate | during hospitalization，assessed up to 28 days |
| In-hospital mortality rate | during hospitalization，assessed up to 28 days |
| ICU length of stay | during hospitalization，assessed up to 28 days |
| Total hospital length of stay | during hospitalization，assessed up to 28 days |
| Duration of invasive mechanical ventilation | during hospitalization，assessed up to 28 days |
| Incidence of Ventilator-Associated Pneumonia (VAP) | during hospitalization，assessed up to 28 days |
| Proportion of patients undergoing tracheostomy | during hospitalization，assessed up to 28 days |
| Time of tracheostomy | among those who receive tracheostomy | during hospitalization，assessed up to 28 days |
| High-risk factors for ventilator dependence in chronic disease patients | during hospitalization，assessed up to 28 days |