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The subjects of this study are the chronic obstructive pulmonary disease (COPD) patients with chronic II respiratory failure. The participants will be divided into two groups: The Portable Home Noninvasive Ventilator treatment group and the routine home oxygen inhalation treatment group. All subjects will be given a stable COPD regimen and conventional oxygen therapy ,but the portable home noninvasive ventilator treatment group will need to wear a portable non-invasive ventilator. Objective evaluation indexes were established during the routine treatment, and two groups of subjects will be followed up for one year. Finally, the clinical data of all subjects will be analyzed,and then the practicability of portable wearable household noninvasive ventilator will be verified.The researchers will also build a remote breathing data-monitoring platform based on mobile internet,and a community home demonstration application point.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| The Portable Home Noninvasive Ventilator treatment group | The patients maintain a stable COPD regimen, and on the basis of conventional home oxygen therapy, a portable, wearable, non-invasive ventilator will be used. | ||
| Routine home oxygen therapy group | The patient maintained a stable COPD regimen and conventional home oxygen therapy. |
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| Measure | Description | Time Frame |
|---|---|---|
| The frequency of the chronic obstructive pulmonary disease(COPD) acute exacerbation. | Record the frequency of COPD acute exacerbation within one year | one year |
| Measure | Description | Time Frame |
|---|---|---|
| The first onset time of the chronic obstructive pulmonary disease(COPD) acute exacerbation | Record the first onset time of COPD acute exacerbation | one year |
| The number of hospitalizations due to the chronic obstructive pulmonary disease(COPD) acute exacerbation |
| Measure | Description | Time Frame |
|---|---|---|
| Six Minute Walk Distance | month0,month4,month8,month12 | |
| pulmonary arterial pressure | month0,month4,month8,month12 | |
| arterial blood gas |
Inclusion Criteria:
Exclusion Criteria:
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The subjects were selected from the Department of respiration, Xinqiao Hospital of Chongqing city.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hu Mingdong, MD | Contact | +86-13500362524 | huhanshandd@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Emergency Department, Xinqiao Hospital, Third Military Medical University | Recruiting | Chongqing | China |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D012131 | Respiratory Insufficiency |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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Record the number of hospitalizations due to the COPD acute exacerbation |
| one year |
| month0,month4,month8,month12 |
| routine analysis of blood | month0,month4,month8,month12 |
| The change of cytokines expression | The cytokines including IL8、IL13、TNF-a、INF-r、IFN-γ、LTB4. | month0,month4,month8,month12 |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012120 | Respiration Disorders |