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The goal of this study is to evaluate the effect of pistachio (Pistacia vera L.) consumption on plasma melatonin, antioxidant capacity, and circadian rhythms in overweight young adults.
The main question it aims to answer are:
This study will provide scientific evidence supporting the biological clock-regulating action of compounds present in pistachios, such as phyto-melatonin, their impact on circadian rhythm regulation, and improvement of metabolic processes altered during obesity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pistacho consumption | Experimental | Participants consumed 28 g (equivalent to 5.6 mg of phytomelatonin) of pistachios each day, specifically 40 pistachios with shells, 1 hour to 30 minutes before bedtime. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pistacho supplementation | Other | Participants consumed 28 g (equivalent to 5.6 mg of phyto-melatonin) of pistachios each day, specifically 40 pistachios with shells, 1 hour to 30 minutes before bedtime |
| Measure | Description | Time Frame |
|---|---|---|
| Body composition analysis | Body composition analysis (BCA, including fat mass [FM] and fat-free mass [FFM], in kg and %) was performed with a seca mBCA 514/515 medical Body Composition Analyzer (Allers Hamburg, Germany). The measurements were conducted in accordance with the guidelines of the International Society for the Advancement of Kinanthropometry (ISAK). | Baseline, 2 weeks, 4 weeks |
| Waist circumference | Waist circumference (WC, in cm) was measured using an ergonomic SECA 201 measuring tape. | Baseline, 2 weeks, 4 weeks |
| Plasma melatonin | Plasma obtained from the same samples of biochemicals determinations. Plasma melatonin levels were measured before and after the intervention using a commercial plasma melatonin kit. | Baseline, 2 weeks, 4 weeks |
| Circadian locomotor activity | A temperature sensor on the wirst, an activity and body position sensor was placed on the participant's arm and a luxometer was worn on the neck with a pendant over the clothing. | Through study completion during 28-days. |
| Questionnaire of activity during the day | Horne and Östberg morning- evening test. Visual Analog Score with a cumulative score scale | Baseline, 2 weeks, 4 weeks |
| Physical activity questionnaire (IPAQ) | Measured with the scale MET-minutes per week" (o MET-min/week) | Baseline, 2 weeks, 4 weeks |
| Pittsburgh Sleep Quality Index (PSQI) |
| Measure | Description | Time Frame |
|---|---|---|
| Concentration of metabolic and lipid parameters | Metabolic parameters, including glucose (mg/dL), cholesterol (HDL-c and LDL-c, mg/dL), and triglycerides (mg/dL). | Baseline, 2 weeks, 4 weeks |
| Plasma antioxidant activity by FRAP method |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidad Autónoma de Querétaro | Querétaro City | Querétaro | 76000 | Mexico |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| ICF | No | No | Yes | Informed Consent Form | Sep 1, 2021 | Jun 1, 2026 | ICF_000.pdf |
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A 28-day, uncontrolled, base-final intervention study
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Cumulative score scale by Gobal PSQI score |
| Baseline, 2 weeks, 4 weeks |
The antioxidant activity in deproteinized plasma was assessed using the ferric reducing antioxidant power (FRAP) assay. Plasma antioxidant activity was measured as milimol equivalent of Trolox/mL.
| Baseline, 2 weeks, 4 weeks |
| Plasma antioxidant activity by ORAC assay. | The antioxidant activity in deproteinized plasma was assessed using the oxygen radical absorbance capacity (ORAC) method." | Baseline, 2 weeks, 4 weeks |