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| Name | Class |
|---|---|
| American Pistachio Growers | OTHER |
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The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pistachio | Experimental | Four days of pistachio snacking, to be consumed mid-morning (1oz; 9-11am), mid-afternoon (1oz; 2-4pm), and pre-sleep (0.5 oz; within 1hr of bedtime), while otherwise maintaining normal dietary habits. An addition snack will be consumed post-exercise (0.5oz). |
|
| Control | No Intervention | Maintain normal dietary habits for four days. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pistachio | Other | Roasted, lightly salted, pistachio kernels (no shell) |
|
| Measure | Description | Time Frame |
|---|---|---|
| resting metabolism | resting metabolic rate (RMR) and substrate utilization (RER) via indirect calorimetry | Day 0 and Day 5 |
| exercise metabolic flexibility | substrate metabolism (RER; indirect calorimetry) throughout a submaximal, graded exercise test | Day 0 and Day 5 |
| post-exercise metabolism | Energy expenditure and substrate metabolism (RER) measured at 0, 30, 60, 90min post-exercise via indirect calorimetry | Day 0 and Day 5 |
| Measure | Description | Time Frame |
|---|---|---|
| Caloric Intake | Average calorie intake (kcal) via 24-hr diet record | Day 0 and Day 4 |
| Carbohydrate Intake | Average carbohydrate intake (grams) via 24-hr diet record |
| Measure | Description | Time Frame |
|---|---|---|
| Physical Activity | Daily (24-hr) steps and intensity minutes via wrist activity tracker | daily continuous (Day 0 to Day 5) |
| Sleep Quantity | Nightly sleep quantity (total time spent asleep; minutes) via wrist worn activity tracker. |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Callie Unrein, MS | Contact | 803-777-5478 | sustainlab@mailbox.sc.edu |
| Name | Affiliation | Role |
|---|---|---|
| Katie R Hirsch, PhD | University of South Carolina | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Public Health Research Center: Clinical Exercise Research Center | Recruiting | Columbia | South Carolina | 29208 | United States |
data may be shared upon reasonable request.
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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Randomized, crossover
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| Day 0 and Day 4 |
| Protein Intake | Average protein intake (grams) via 24-hr diet record | Day 0 and Day 4 |
| Fat Intake | Average fat intake (grams) via 24-hr diet record | Day 0 and Day 4 |
| Nightly (Day 0 to Day 5) |
| Sleep Quality | Nightly sleep quality (time spent in deep sleep (minutes), REM sleep (minutes), and light sleep (minutes)) via wrist worn activity tracker. | Nightly (Day 0 to Day 5) |
| Daytime sleepiness | Subjective likelihood of falling asleep in various situations via Epworth Sleepiness Scale. In this eight question survey, questions are rated on a scale of 0 (very unlikely) to 3 (very likely), with a total score of 0-9 indicating low daytime sleepiness, 10-15 indicating moderate daytime sleepiness, and 16-24 indicating severe daytime sleepiness. | Day 0 and Day 5 |
| Subjective hunger | Degree of hunger/fullness (Visual Analog Scale) mid-morning (post-snack), late morning (a few hours post snack), and mid-afternoon (pre-snack). | Daily (Day 1 to Day 4) |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |