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This study being done to learn more about the use of medical Magnetic Resonance Imaging (mMRI) and dedicated dental MRI (ddMRI) as a non-invasive diagnosing tool when evaluating potential oral cancerous and precancerous lesions in Fanconi Anemia patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| FA patients with a history of HNSCC | This group will receive both mMRI and ddMRI, with an exam, every 3-4 months for 2 years (up to 16 scan (+exam) visits). |
| |
| FA patients with no history of HNSCC | This group will receive two scans each of mMRI and ddMRI, with an exam, one year apart (up to 4 scan (+exam) visits). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRIs | Diagnostic Test | mMRI and ddMRI |
|
| Measure | Description | Time Frame |
|---|---|---|
| sensitivity of mMRI and ddMRI in identifying dysplastic and malignant lesions in FA patients. | Proportion of positive lesions correctly diagnosed | Immediately after MRI |
| specificity of mMRI and ddMRI in identifying dysplastic and malignant lesions in FA patients. | Proportion of negative lesions correctly diagnosed | Immediately after MRI |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with Fanconi anemia
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Carla Campbell, BS | Contact | 612-625-6976 | camp2757@umn.edu |
| Name | Affiliation | Role |
|---|---|---|
| Rachel Uppgaard | University of Minnesota | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Minnesota | Recruiting | Minneapolis | Minnesota | 55455 | United States |
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| ID | Term |
|---|---|
| D005199 | Fanconi Anemia |
| ID | Term |
|---|---|
| D029502 | Anemia, Hypoplastic, Congenital |
| D000741 | Anemia, Aplastic |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
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| D006425 |
| Hemic and Lymphatic Diseases |
| D000080984 | Congenital Bone Marrow Failure Syndromes |
| D000080983 | Bone Marrow Failure Disorders |
| D001855 | Bone Marrow Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D049914 | DNA Repair-Deficiency Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |