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| ID | Type | Description | Link |
|---|---|---|---|
| EDGE 166436 | Other Identifier | King's College London |
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Magnetic Resonance Imaging (MRI) has is a useful diagnostic tool that offers advantages over conventional radiography techniques. Unlike traditional X-ray or computed tomography (CT) scans, MRI utilizes a magnetic field and radio waves to generate detailed and high-resolution images of the body's internal structures. This non-invasive imaging modality allows the clinician to better see soft tissues in 3D without the use of ionising radiation. Furthermore, MRI enables the detection and characterization of a wide range of pathologies which can lead to improved diagnostic capabilities and better patient outcomes.
To date, the use of MRI in dentistry has been limited as dentistry imaging focuses predominantly on hard tissues (teeth and bones) in addition to the higher cost and accessibility issues with MRI machines.
However, recent developments have led to the development of a dental-specific coil for use with a low field strength (0.55 Tesla) MRI scanner. This has resulted in high diagnostic quality soft and hard tissue images and reduced imaging time. As this imaging modality has rarely been used before in dentistry, the aim of this study is to investigate its use for dental imaging, refining parameters and assessing the diagnostic quality of dental scans taken using MRI and the specific dental coil.
The overall aim of this feasibility project is to optimise MRI parameters for dental use (i.e., dental-dedicated MRI) and assess the diagnostic quality of dental scans taken using MRI.
The objectives are to assess if MRI imaging has altered the diagnosis, retrospectively analyse the numbers of patients which can be diagnosed effectively using this radiation free imaging modality and document health resource use to inform a full health technology assessment trial.
The primary objective is to assess the feasibility of providing MRI scanning to dental patients and the resultant benefit. As such, the investigators will examine the percentage of patients whose diagnosis was altered as a result of additional MRI scanning.
The secondary objectives are to assess:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients requiring orofacial imaging | Patients requiring orofacial imaging, provided their treating clinician would see significant value in obtaining an MRI image |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magnetic Resonance Imaging | Other | Participants will receive an additional MRI image in addition to standard of care to investigate if it was a useful imaging modality for their condition |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of patients whose diagnosis/care changed as a result of the additional dental MRI imaging compared to the total number of patients imaged using conventional radiography. | The treatment plan that was given before the MRI scan will be documented. Following review of the MRI by the overseeing consultant, any changes to the treatment plan will be documented. The number of patients whose treatment plan was altered as a result of the scan will be divided by the number of those who received a scan to get a percentage. | 4 weeks |
| To assess diagnostic quality of the image | This is a feasibility trial and a new imaging modality for dentistry. Working with MR physicists we will assess image quality and report on areas for improvement | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of patients whereby the diagnosis could have been obtained using dental-dedicated MRI alone | The number of patients whereby the clinical indicators of pathology on the MRI scan were sufficient to gauge the pathology will be assessed. This will be divided by the number of patients who received a scan to get a percentage. | 4 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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Patients requiring orofacial imaging or healthy volunteers, provided their treating clinician would see significant value in obtaining an MRI image
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Saoirse O'Toole, BDentSc PhD | Contact | +442078485643 | saoirse.otoole@kcl.ac.uk | |
| Jonathan Consultant Maxillofacial Radiologist | Contact | +442078487343 | jonathan.1.davies@kcl.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Saoirse O'Toole, BDentSc PhD | King's College London | Principal Investigator |
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We can publish the results of the data but not participant scans or any identifiers.
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Mar 14, 2025 | May 29, 2025 | Prot_SAP_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | Mar 14, 2025 | May 29, 2025 | ICF_001.pdf |
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| ID | Term |
|---|---|
| D009682 | Magnetic Resonance Spectroscopy |
| ID | Term |
|---|---|
| D013057 | Spectrum Analysis |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
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| Time spent undergoing scan |
Time spent undergoing scan (minutes) |
| 4 weeks |
| Radiation exposure (Grays) | Radiation exposure of the imaging modality (Grays) | 4 weeks |