Comparison Immune Response in Paravertebral and Erector Spinal Plane Block in Breast Cancer Patients

Immunologic Response in Breast Cancer Before and After Application of Paravertebral and Erector Spinae Plane Block

The goal of this clinical trial is to find the difference in immune response between two types of regional anesthesia in female patients suffering from breast cancer.

The main question it aims to answer is there a difference in the immune response between paravertebral block and erector spinal plane block.

Hypothresis of the study is that paravertebral block with propofol induces less immune response in surgical treatment of breast cancer patients than erector spinal plane block.

Participants will be asked to sign the informant consent. They will be given either paravertebral block or erector spinae plane block with general anesthesia using propofol. Their venous blood will be taken 1 hour prior surgery and 24 and 48 hours after surgery.

Inclusion Criteria:

• ASA I and ASA II status, normal BMI

Exclusion Criteria:

• ASA III and ASA IV status, coagulopathy, chronic opioid use, diabetes, local infection of the skin