The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level. Individual multi-system clinical data from enrolled participants are linked to a continuously-ingested ecological data infrastructure spanning environmental exposures, social determinants, genealogical and family history records, mortality data, and population health databases at geographic resolutions from home address to global scale and beyond. The resulting model generates individual screening recommendations informed by population-level causal estimates, and population-level causal forecasts anchored by present-timepoint individual clinical biology. Thus creating a feedback architecture designed to improve both simultaneously.

Existing approaches to human health prediction face a structural limitation: individual clinical studies measure biology without capturing the environment, while population epidemiology captures the environment without individual biological ground truth. The Human Observatory Study resolves this by operating at both levels simultaneously through a linked dual-layer architecture.

At the individual level, participants enrolled in the 100-Year Human Aging Study contribute comprehensive multi-system health measurements. This includes clinical, physiological, cognitive, behavioral, social, occupational, and environmental data collected at fixed and mobile clinical sites. These measurements provide the biological present timepoint that historical population data alone cannot supply.

At the population level, the Observatory continuously ingests ecological data from public and private registries across multiple input domains. This includes air quality, water and chemical contaminants, wildfire and smoke exposure, altitude and terrain, climate, satellite earth observation, occupational and industrial exposure, mortality and vital statistics, demographics and social determinants, and clinical data networks at geographic resolutions from home address to global scale and beyond. This ecological layer captures the environmental and social causal structure of health and disease continuously and does not require individual enrollment.

A foundational input domain is genealogy and family history. Health and disease run in families across generations. The Observatory is designed to build and continuously expand a linked genealogical database connecting living and historical individuals to their family health histories. Information is obtained from public genealogical records, death registries, family history self-report, and genetic data where available. The long-term vision is a genealogical infrastructure of sufficient depth and breadth to trace familial health patterns across the full recorded human family tree. Therefore connecting individual present-timepoint biology to multigenerational patterns of disease, longevity, and environmental exposure that no existing biobank or longitudinal study has attempted to capture at this scale.

The linked architecture enables a feedback loop with two outputs: population-level causal estimates that inform individual screening recommendations, and individual clinical data that give population models a present biological anchor for prospective forecasting. The degree to which each input domain, alone and in combination, predicts health, disease, and death across geographic scales from neighborhood to global and beyond is the central scientific question the Observatory is designed to answer.

The Observatory launches in Colorado, chosen as the founding site for its exceptional natural variation in altitude, wildfire smoke corridors, mining and industrial chemical geographies, and frontier-to-urban socioeconomic gradient all within a compact, well-characterized geography with established academic research infrastructure. Colorado proves the model. The architecture then replicates geographically, with each new location enriching the world model for every other. The long-term vision is global coverage and beyond. Every geography will contribute its environmental, social, and biological signal to a world model that gets more accurate with every geography studied, every participant enrolled, every dataset ingested, and every causal analysis conducted.

Inclusion Criteria:

• Enrolled in the 100-Year Human Aging Study at any fixed or mobile clinical site; OR completion of online health screener with provision of geographic anchor data and consent.

Exclusion Criteria:

• Age under 18 years (current protocol; pediatric amendment planned).

Participants of all ages, health statuses, and demographic backgrounds enrolled in the 100-Year Human Aging Study at any fixed or mobile clinical site, plus participants completing the online health screener. No exclusions based on health status, geographic location, language, or population group. The ecological surveillance layer requires no individual enrollment.