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| Name | Class |
|---|---|
| Pirogov Russian National Research Medical University | OTHER |
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This is an observational cohort study of long-living adults (participants aged 90 and above) from the Central Federal District of Russia.
The study seeks to determine the genetic and cellular and molecular determinants of healthy longevity and to assess the impact of lifestyle and socioeconomic and environmental factors on healthy longevity.
The study is expected to result in the development of a panel of markers of healthy longevity and/or a model of healthy aging based on the analysis of all factors under consideration.
The study involves a long-term observation of a cohort of long-living adults. During the first visit, a medical professional will take a detailed medical history and perform a comprehensive geriatric assessment (for 15 geriatric syndromes), and physical examination. The participants will have their biomaterials sampled for basic and extended blood biochemistry testing, telomere length measurement, common urine tests and subsequent biobanking and additional studies: whole genome sequencing, DNA methylation analysis, transcriptome analysis, and 16S RNA sequencing of stool and saliva.
Follow-up checks will be carried out once a year by phone or during additional visits.
The study seeks to identify the genetic, epigenetic, and metagenomic determinants associated with the successful and unsuccessful aging phenotypes, mortality, and survival in long-living individuals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Long-living individuals | Long-living individuals at least 90 years of age from the Central Federal District of Russia |
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| Measure | Description | Time Frame |
|---|---|---|
| Mortality among long-living adults | Mortality among long-living adults within at least 1 year after inclusion in the study and factors associated with mortality will be assessed. | at least 1 year after inclusion in the study |
| Morbidity among long-living adults | Morbidity among long-living adults within at least 1 year after inclusion in the study and factors associated with morbidity will be assessed. | at least 1 year after inclusion in the study |
| Measure | Description | Time Frame |
|---|---|---|
| Aging phenotypes | Identification of successful and unsuccessful aging phenotypes | at least 2 years after inclusion in the study |
| Social, economic, and medical- history-related determinants | Identification of social, economic, and medical- history-related determinants of successful and unsuccessful aging, geriatric syndromes |
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Inclusion Criteria:
Exclusion Criteria:
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The inclusion of participants will be carried out with the involvement of social services, boarding houses for labor veterans, geriatric centers and other geriatric services in the central region of Russia
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Daria A. Kashtanova, M.D., Ph.D | Contact | +74955406171 | 4120 | DKashtanova@cspfmba.ru |
| Veronika V. Erema, M.D., Ph.D | Contact | +7 (495) 540-61-71 | 4136 | VErema@cspfmba.ru |
| Name | Affiliation | Role |
|---|---|---|
| Irina D. Strazhesko, M.D., Ph.D | Pirogov Russian National Research Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| RUSSIAN CLINICAL AND RESEARCH CENTER OF GERONTOLOGY, Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation | Recruiting | Moscow | 129226 | Russia |
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| ID | Term |
|---|---|
| D000073496 | Frailty |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Whole blood, serum, stool, saliva, urine
| at least 2 years after inclusion in the study |
| Genetic determinants | Identification of the genetic determinants of successful and unsuccessful aging, geriatric syndromes | at least 2 years after inclusion in the study |
| Epigenetic determinants | Identification of the epigenetic determinants (methylation sites) of successful and unsuccessful aging, geriatric syndromes | at least 2 years after inclusion in the study |
| Metagenomic determinants | Identification of the metagenomic determinants (16S-rSeq) of successful and unsuccessful aging, geriatric syndromes | at least 2 years after inclusion in the study |
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