Clinical Study on a New Diagnostic Strategy for Osteoporosis and Sarcopenia in Chronic Kidney Disease Patients Based on MRI-FF

A Clinical Study on Establishing a New Diagnostic Strategy for Osteoporosis and Sarcopenia in Patients With Chronic Kidney Disease Based on MRI-FFR

This is a single-center, observational cohort study aiming to validate the diagnostic value of MRI-FF in identifying osteoporosis and sarcopenia in patients with chronic kidney disease (CKD). A total of 868 participants, including 434 CKD patients and 434 non-CKD controls, will be enrolled at Beijing Jishuitan Hospital. All subjects will undergo MRI-FF scans of the lumbar spine and thigh to assess bone mineral density and muscle fat fraction. The primary objective is to evaluate the correlation between MRI-FF parameters and conventional diagnostic criteria for osteoporosis and sarcopenia, as well as to determine the optimal cut-off values for early detection. The study duration is from March 2026 to December 2028.

Inclusion Criteria:

1. Age between 18 and 80 years old.
2. Able to understand and sign the informed consent form.
3. Able to complete MRI-FF scans of the lumbar spine and thigh.
4. For CKD group: Confirmed diagnosis of chronic kidney disease (eGFR < 60 mL/min/1.73m² for ≥3 months).
5. For control group: No history of chronic kidney disease and normal renal function.

Exclusion Criteria:

1. Contraindications to MRI (e.g., pacemaker, metal implants, severe claustrophobia).
2. History of primary bone metabolic disorders (e.g., osteoporosis, hyperparathyroidism) unrelated to CKD.
3. Current use of anti-osteoporotic drugs (e.g., bisphosphonates, teriparatide).
4. Severe lower limb deformity or amputation affecting thigh muscle assessment.
5. Inability to cooperate with the scan due to cognitive impairment or severe illness.