Sarcopenia, Fall and Osteoporosis in Chronic Kidney Disease

Sarcopenia, Fall and Osteoporosis in Patients With Chronic Kidney Disease

This study is a cross-sectional study that wishes to investigate whether there is an increased incidence of sarcopenia in patients with chronic kidney disease compared to the Danish background population. A possible association between sarcopenia and fall, as well as the incidence of osteoporosis in patients with chronic kidney disease will also be described.

Sarcopenia is a condition diagnosed from different clinical findings such as low muscle mass, low muscle strength and possibly also poor physical performance. In the general population, the risk of fall and bone fracture increases, when sarcopenia is also present.

Sarcopenia is known to occur in patients with chronic kidney disease, but whether, and if so, how this differs from the incidence in patients without kidney disease has not previously been described.

Patients with chronic kidney disease have a 3 times higher risk of bone fracture compared to the Danish background population, and they also have an increased risk of falls.

The association between sarcopenia, risk of falls and osteoporosis in patients with kidney disease is until now sparsely described, and because of this, the investigators want to explore this further in this cross-sectional study.

Inclusion Criteria:

• Age ≥20 years
• Chronic kidney disease stage 4-5 not on dialysis (nonD) (corresponding to an estimated glomerular filtration rate (eGFR) ≤30 ml/min based on Kidney Disease Improving Global Outcomes (KDIGO) definition and not on dialysis)

Exclusion Criteria:

• Kidney transplanted
• Immobilized/hospitalized for more than 1 week within the last 6 weeks
• Active treatment with growth hormone or sex hormone
• Known muscle disease
• The lack of ability to speak or understand Danish
• The lack of ability to give an informed consent
• The lack of ability to participate in a clinical study based on the assessment by the local investigator