Diagnosis and Treatment of Lung Lesions

A Study on the Feasibility and Safety of Single-Session Robot-Assisted Bronchoscopy for Diagnosis and Ablation of Pulmonary Lesions

To evaluate the safety and feasibility of a single-session "diagnose and treat" (one-stop) paradigm utilizing robotic-assisted bronchoscopy (RAB).

The increasing detection of peripheral pulmonary lesions (PPLs) necessitates effective, lung-sparing therapies. For inoperable patients, current guidelines dictate a staged workflow involving diagnostic biopsy followed by a separately scheduled ablation. This study aims to evaluate the safety and feasibility of a single-session "diagnose and treat" (one-stop) paradigm utilizing robotic-assisted bronchoscopy (RAB).

Inclusion Criteria:

1. Age ≥18 years.
2. Have peripheral pulmonary lesions (PPLs).
3. Meet at least one of the following conditions: (1) Deemed medically inoperable due to surgical intolerance; (2) Have newly developed or residual nodules after previous lung cancer surgery; (3) Present with multiple bilateral pulmonary nodules; or (4) Explicitly refuse surgical resection.

Exclusion Criteria:

1. Centrally located tumors invading the main bronchi.
2. Uncorrectable coagulopathy.
3. Evidence of advanced nodal (N2/N3) or distant metastatic disease (unless the PPL represented an oligometastatic lesion targeted with curative intent).