Aortic Dissection Detection Risk Score With D-dimer to Rule-Out Acute Aortic Syndrome

ClinicalTrials.gov ID

NCT07640334

Lead Sponsor

Chinese University of Hong KongOTHER

Overall Status

Not yet recruiting

Study Type

Observational

Enrollment

746Estimated

Last Update Posted

Aug 5, 2026Actual

Start Date

Jul 13, 2026Estimated

Primary Completion Date

Jun 30, 2028Estimated

Completion Date

Dec 31, 2028Estimated

Official Title

The Combination of Aortic Dissection Detection Risk Score With D-dimer to Rule-Out Acute Aortic Syndrome: Multicentre Prospective Study in Emergency Departments

Brief Summary

The goal of this study is to evaluate the safety of integrating the Aortic Dissection Detection Risk Score (ADD-RS) and D-dimer testing for ruling out acute aortic syndrome (AAS) in the emergency department (ED). The main question it aims to answer: Can the combination of the ADD-RS <2, and D dimer <500ng/mL rule-out AAS in ED patients without CTA? The researchers will recruit patients suspected with AAS in the ED, and the patients will receive a ADD-RS score, a D-dimer testing after signing a written consent.

• Acute Aortic Syndrome

• D-dimer test

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

• Adult patients aged ≥ 18 years; AND
• Presentation to the ED with any of the following symptoms: acute onset (<14 days) chest pain, abdominal pain, back pain, syncope, or signs of malperfusion (e.g. limb ischemia, neurological deficit); AND
• AAS is considered as a possible differential diagnosis by the treating physician. Enrolment in the study will be determined by the attending physician during initial medical consultation in the ED and prior to establishing a final diagnosis.

Exclusion Criteria:

• An alternative diagnosis to AAS established by the treating physician after the initial assessment; OR
• Trauma cases; OR
• Patients with a known diagnosis of AAS before the index ED visit (e.g. with a diagnostic imaging done before the ED visit or referral from other institutions for AAS); OR
• Clinical severity or other conditions not allowing complete evaluation/proper enrolment; OR
• Patient who refuse to participate.

Observational Model

Cohort

Time Perspective

Prospective

Lead Sponsor

Chinese University of Hong KongOTHER

Collaborators

Prince of Wales Hospital, Shatin, Hong KongOTHER

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