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This is a proof-of-concept study exploring individual differences in sensitivity to alcohol among older healthy current drinkers aged 65 to 80. Participants will complete two sessions during which they will complete questionnaires and laboratory measures of mental abilities and brain activity and receive a beverage that may or may not contain a moderate dose of alcohol.
As a preliminary, proof-of-concept study, the project is designed to provide information regarding variability in response to a moderate dose of alcohol among healthy men and women who are current drinkers and aged 65 to 80. It is expected that approximately 75 individuals will complete the study. Participants complete two laboratory sessions. Each session will include consuming a beverage that may or may not include alcohol. If the beverage does include alcohol, the volume will not exceed the amount that a drinker might consume in 1 to 2 drinks. The outcomes will provide information regarding the how older adults vary in their response to alcohol and explore whether alcohol sensitivity is related to selected measures of cognition.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alcohol Condition | Experimental | Beverage contains an alcohol volume consistent with achieving a sub-intoxicating breath alcohol concentration |
|
| Non-Alcohol Session | Placebo Comparator | Placebo beverage is administered |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Alcohol (Oral) | Other | Described elsewhere |
| |
| Placebo Control |
| Measure | Description | Time Frame |
|---|---|---|
| Alcohol Effects on Psychomotor Skills as reflected in the Trail Making Test (TMT) | Difference between the number of seconds required to complete the TMT under placebo vs the alcohol condition for each individual | The placebo and alcohol sessions occur ~ 10-14 days apart. |
| Alcohol Effects on a Working Memory Task requiring Continuous Recognition | Differences in accuracy in identifying previously seen vs. new items a working memory task under alcohol vs placebo conditions for each individual | The placebo and alcohol sessions occur ~ 10-14 days apart. |
| Alcohol Effects on Neural Activity Measured from Scalp Electroencephalography | Differences in neural activity as reflected obtained through non-invasive electroencephalography under alcohol vs placebo conditions for each individual | The alcohol and placebo sessions occur ~ 10-14 days apart. |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between alcohol sensitivity and standard cognitive assessment | Correlations between differences under alcohol vs placebo conditions for the psychomotor task, the working memory task, the measure of neural activity and performance on a general measure of cognitive abilities | The general measure of cognitive abilities is obtained in the first session, prior to the experimental condition. The difference scores are derived by comparing outcomes between alcohol vs placebo sessions which are ~ 10-14 days apart. |
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Inclusion Criteria
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sara Jo Nixon, PhD | Contact | 352-294-4920 | sjnixon@ufl.edu | |
| Ben Lewis, PhD | Contact | 352-294-4920 | benlewis@ufl.edu |
| Name | Affiliation | Role |
|---|---|---|
| Sara Jo Nixon, PhD | University of Florida | Principal Investigator |
| Ben Lewis, PhD | University of Florida | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Florida | Gainesville | Florida | 32610 | United States |
Data will be made available through an NIH repository.
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| ID | Term |
|---|---|
| D000431 | Ethanol |
| ID | Term |
|---|---|
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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| Other |
on each of two visits, participants receive either the placebo drink or the drinking containing alcohol |
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