Participants will receive an health-related message included in the biological results form. A short graphical illustration will indicate the patient-risk level according the biological results and video detailing national recommendations.

HCPs will receive a SIGNAL BIO message which was elaborated on evidence-based treatments and/or strategy for patients with diabetes.

Participants will get as in the routine care, no message will be disseminated for this group.

Patient will be included in the intervention according to the laboratory's randomization arm.The intervention consists in delivering patient information messages in laboratory reports, providing access to an educational video for patients and a specific message for the prescribing physician in the intervention arm, without modifying patient care.

Change in Major Adverse Renal and Cardiovascular Events (MARCE) occurrence defined as a composite outcome including the following items (first occurring):

• All-cause death
• Myocardial infarction (universal definition)
• Stroke (universal definition)
• Sustained (over 45 days) use of renal replacement therapy
• Heart failure leading to hospitalization (definition by the European Society of Cardiology)

Change in specific health outcomes (separately analysed):

• All-cause death
• Myocardial infarction
• Stroke
• Sustained (over 1 month) use of renal replacement therapy
• Heart failure leading to hospitalization
• Lower limb amputation, with special information on the site of amputation (toe, transmetatarsal, transtibial, transfemoral)
• Arterial revascularization in the coronary, cerebrovascular and/or lower aorta/lower limb territories
• Severe diabetic retinopathy (laser procedure, eye surgery for diabetes complication and intravitreal injection associated with specific drug delivery and/or their combinations