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| ID | Type | Description | Link |
|---|---|---|---|
| 1R01DK142774-01 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | NIH |
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Many teenagers get too little and late timed sleep. High body weight and diabetes are increasing in teenagers as well. This study plans to learn more about whether improving sleep habits can help improve how the body regulates blood sugar and energy use in teenagers who have higher body weight. To answer this question, the investigators plan to enroll teenagers who get <7 hours of sleep on school nights and measure changes in blood sugars and energy use after two weeks of typical sleep (sleeping on their normal school schedule) and two weeks of a sleep intervention that includes spending longer time in bed at night, melatonin, and morning light.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Typical Sleep | No Intervention | Habitual sleep schedule | |
| Circadian/Sleep (C/S) Condition | Experimental | 1h additional time in bed, melatonin 2h before bedtime, and 30 minutes bright light after waking |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Circadian/Sleep (C/S) | Behavioral | 1h additional time in bed, melatonin 2h before bedtime, and 30 minutes bright light after waking |
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| Measure | Description | Time Frame |
|---|---|---|
| Insulin sensitivity | Matsuda Index will be calculated from a mixed meal tolerance test (MMTT); higher values indicate better insulin sensitivity. | Assessed at 2 weeks following each condition |
| Measure | Description | Time Frame |
|---|---|---|
| Total daily energy expenditure (TDEE) | Assessed with doubly labeled water. Higher values indicate greater energy expenditure | Assessed for two weeks during each condition |
| Average daily caloric intake (kcal/day) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Stacey L Simon, PhD | Contact | 720-777-5681 | stacey.simon@childrenscolorado.org | |
| Angel Arias, BS | Contact | 720-777-3491 | angel.arias@childrenscolorado.org |
| Name | Affiliation | Role |
|---|---|---|
| Stacey L Simon | University of Colorado, Denver | Principal Investigator |
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Data obtained through this study may be provided to qualified researchers with academic interests. Data shared will be coded, with no PHI included. Approval of the request and execution of all applicable agreements (i.e. a material transfer agreement) are prerequisites to the sharing of data with the requesting party.
Data requests can be submitted starting 9 months after article publication and the data will be made accessible for up to 24 months. Extensions will be considered on a case-by-case basis.
Access to study IPD can be requested by qualified researchers engaging in independent scientific research, and will be provided following review and approval of a research proposal and Statistical Analysis Plan (SAP) and execution of a Data Sharing Agreement (DSA). For more information or to submit a request, please contact clinicalresearchsupportcenter@ucdenver.edu.
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D012890 | Sleep |
| ID | Term |
|---|---|
| D009424 | Nervous System Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Calculated from photographic diet diaries. Higher kcal indicates greater caloric intake.
| Measured for 3 days during each condition |