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| ID | Type | Description | Link |
|---|---|---|---|
| K23DK117021 | U.S. NIH Grant/Contract | View source | |
| R03DK131225 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | NIH |
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Many teenagers do not get enough sleep. Obesity and diabetes are increasing in teenagers as well. This study plans to learn more about sleep and insulin resistance (insulin not working) in teenagers, and how these things may be related depending on sleep. This is important to know so that the investigators understand how sleep may play a role in health conditions like extra weight gain (increased food intake and less physical activity) and diabetes. To answer this question, the investigators plan to enroll teenagers who get <7 hours of sleep on school nights and measure changes in insulin sensitivity and dietary intake after a week of typical sleep (sleeping on their normal school schedule) and a week of longer sleep (spending 1+ hour longer in bed each night).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Typical Sleep | No Intervention | All participants will sleep for 6 nights (Sunday - Thursday) in the home environment per their usual school schedule. | |
| Sleep Extension | Experimental | Participants will be prescribed a sleep schedule that allows them to obtain 1 hour more time in bed compared to Typical Sleep. For participants completing the study September 2021 and later, they will also be instructed to take exogenous melatonin (500mcg) and maintain dim light conditions 2 hours before bedtime, and use light glasses for 30 minutes in an upright position after waking in the morning (Sleep Extension + Circadian Manipulation). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sleep Extension | Behavioral | Participants will be asked to increase time in bed at least 1 hour more than baseline |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Insulin Sensitivity | Insulin sensitivity assessed two times with an insulin-modified intravenous glucose tolerance test. | 2 weeks after Baseline and 7 weeks after Baseline |
| Change in Sleep Duration & Timing | Assessed three times with a wrist-worn Actigraphy | At Baseline, 1 week after Baseline, and 6 weeks after Baseline |
| Change in Physical activity | Assessed three times with a triaxial thigh-worn ActivPal | At Baseline, 1 week after Baseline and 6 weeks after Baseline |
| Change in Dietary Intake | Participants will be asked to complete diet diaries two times for 3 days during each sleep condition (prior to each overnight assessment), listing all food and drink consumed, estimated portion size, and timing of consumption. | 1 week after Baseline and 6 weeks after Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Change in glycemic variability | Assessed two times with a continuous glucose monitor | 2 weeks after Baseline and 7 weeks after Baseline |
| MTNR1B rs10830963 SNP | Genotyping will be conducted on saliva samples |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stacey Simon, PhD | Children's Hospital Colorado and University of Colorado Anschutz Medical Campus | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Children's Hospital Colorado | Aurora | Colorado | 80045 | United States |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Oct 22, 2025 | |
| Reset | Nov 5, 2025 | |
| Release | Nov 25, 2025 | |
| Reset | Dec 5, 2025 | |
| Release | Apr 10, 2026 | |
| Reset | Apr 30, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Oct 22, 2025 | Nov 5, 2025 | |||
| Nov 25, 2025 |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D005247 | Feeding Behavior |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| 2 weeks after Baseline |
| Dec 5, 2025 |
| Apr 10, 2026 | Apr 30, 2026 |
| D001522 | Behavior, Animal |
| D001519 | Behavior |