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| Name | Class |
|---|---|
| Institut Pasteur de Guadeloupe | UNKNOWN |
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Chlordecone, an organochlorine pesticide used in the French Caribbean for several decades, is recognized as an endocrine disruptor. Accumulation in thyroid tissue may be modeled using several factors, including blood chlordecone levels, environmental exposure associated with place of residence, and dietary habits.
Chlordecone, an organochlorine pesticide, is recognized as an endocrine disruptor. Following ingestion, this molecule is preferentially stored in the liver and, to a lesser extent, in adipose tissue. The development of thyroid goiter may be promoted by exposure to certain substances. Environmental pollutants have been shown to increase TSH secretion, and prolonged exposure to endocrine disruptors affecting the pituitary-thyroid axis has been associated with thyroid neoplasia.
Currently, exposure to chlordecone is assessed through measurement of chlordeconemia (plasma concentration), reflecting exposure during the months preceding sampling and providing an estimate of body burden at the time of assessment. However, chlordecone impregnation in thyroid tissue and adjacent structures has not yet been investigated in humans.
The aim of this study is to model chlordecone concentration in tissues using chlordeconemia, occupational activity, dietary habits, and place of residence.
A biological collection will be established and stored at the Biological Resources Center (CRB) of the University Hospital to support the primary and secondary objectives. Blood, adipose tissue, and thyroid tissue samples will be collected.
The inclusion period will last 11 months, each participant will be involved for 4 months, and the total study duration will be 16 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants undergoing thyroid surgery | Other | Participants undergoing thyroid surgery with prospective collection of blood, thyroid tissue, and adjacent adipose tissue samples for chlordecone concentration assessment and evaluation of exposure-related factors. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood and thyroid tissue collection | Other | Collection of blood, thyroid tissue, and adjacent adipose tissue samples during routine thyroid surgery for measurement of chlordecone concentration and assessment of exposure-related factors. |
| Measure | Description | Time Frame |
|---|---|---|
| chlordecone concentration in the adipose tissue adjacent to the thyroid | Chlordecone concentration measured in adipose tissue adjacent to the thyroid collected during thyroid surgery. | During surgery |
| Chlordecone concentration in blood | Chlordecone concentration measured in blood samples collected one day before surgery. | 1 day before surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Occupational exposure category | Occupational activity classified as high or low potential exposure to chlordecone based on professional activity collected through a self-administered questionnaire. Agricultural workers and livestock breeders will be classified as high exposure occupations | At enrollment |
| Residential environmental exposure assessment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| mélanie petapermal, Master degree | Contact | +590590934667 | +590 | melanie.petapermal@chu-guadeloupe.fr |
| Name | Affiliation | Role |
|---|---|---|
| suzy Duflo, MD PhD | CHU de la Guadeloupe | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de la Guadeloupe | Les Abymes | 97159 | Guadeloupe |
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Observational, analytical, single-center, cross-sectional study with prospective data collection.
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Environmental exposure assessment based on residential history during the previous 10 years. Residential addresses reported for periods longer than 3 months will be geolocated and linked to soil contamination maps established by CIRAD. |
| At enrollment |
| Dietary exposure assessment | Dietary habits assessed using a self-administered questionnaire collecting information on food consumption patterns and food origin. | At enrollment |
| ID | Term |
|---|---|
| D013959 | Thyroid Diseases |
| ID | Term |
|---|---|
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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