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| ID | Type | Description | Link |
|---|---|---|---|
| 2023-A01755-40 | Registry Identifier | ANSM |
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| Name | Class |
|---|---|
| Institut Pasteur de Guadeloupe | UNKNOWN |
| Rennes University Hospital | OTHER |
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Chlordecone is an organochlorine pesticide used in the French West Indies (FWI) from 1972 to 1993 to control the banana root borer. Due to its very long persistence the population continues to be exposed to this chemical through their food consumptions. Although, chlordecone have been associated in animal study impairment of ovarian reserve, to date, no study has been published concerning the link between chlordecone exposure and female fertility. The main objective of this project is to study the association between chlordecone exposure and anti-mullerian hormone (AMH) in women consulting for couple infertility in Guadeloupe.
Chlordecone is an organochlorine pesticide used in the French West Indies (FWI) from 1972 to 1993 to control the banana root borer. Due to its very long persistence the population continues to be exposed to this chemical through their food consumptions. Chlordecone is an endocrine-disrupting chemical with well-defined estrogenic and progestagenic properties in vivo and in vitro. To date, no study has been published concerning the link between chlordecone exposure and female fertility. Nevertheless, mammalian studies in females have consistently reported that chlordecone exposure impairs ovulation and leads to a reduced ovarian reserve. In addition, there are questions about the impact of other environmental exposures, including by non-targeted approaches, and also of the vaginal and endometrial microbiome on female fertility.
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| Measure | Description | Time Frame |
|---|---|---|
| Levels of AMH according to terciles of chlordecone levels. | The purpose is to study the association between chlordecone exposure and AMH levels in women consulting for couple infertility in Guadeloupe. | AMH levels will be measured during the assessment conducted for assisted reproductive technology (ART) and will date from less than one year before inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Number of antral follicles according to terciles of chlordecone levels. | Transvaginal ultrasound for antral follicle count will be performed between days 2 and 4 of the spontaneous menstrual cycle, the number of antral follicles corresponds to the total number of antral follicles in both ovaries, with a diameter between 2 and 10 mm. | between days 2 and 4 of the spontaneous menstrual cycle |
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Inclusion Criteria:
Exclusion Criteria:
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Women consulting for couple infertility in Guadeloupe.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mélanie petapermal | Contact | +590590934667 | melanie.petapermal@chu-guadeloupe.fr | |
| Valérie Hamony Soter | Contact | +590590934677 | valerie.soter@chu-guadeloupe.fr |
| Name | Affiliation | Role |
|---|---|---|
| Ronan Garlantezec, MD PhD | CHU de Rennes - Université de Rennes | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu de La Guadeloupe | Recruiting | Pointe-à-Pitre | 97159 | Guadeloupe |
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| ID | Term |
|---|---|
| D007247 | Infertility, Female |
| D011085 | Polycystic Ovary Syndrome |
| D004715 | Endometriosis |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| AMH levels and antral follicle count according to the levels of other POPs | AMH levels and antral follicle count | baseline |
| relationship between exposure to chlordecone and other POPs and the risk of the main causes of female infertility | main causes of female infertility : Endometriosis ; Polycystic ovary syndrome (PCOS) ; Decreased ovarian reserve | baseline |
| Chlordecone levels according to the outcomes of IVF/ICSI management: | relationship between occupational exposure to solvents and others factors described :
| changes from baseline to 2 years after |
| D000091662 | Genital Diseases |
| D007246 | Infertility |
| D010048 | Ovarian Cysts |
| D003560 | Cysts |
| D009369 | Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |