Outcomes of Conventional Root Canal Treatment Compared to Regenerative Endodontics, and Cleaning and Shaping Only in Mature Upper First Premolars

The Effect of Regenerative Endodontic Procedures and Only Cleaning and Shaping on The Outcome of Adult Mature Permanent Necrotic Teeth: A Randomized Clinical Trial

It was to compare clinically between the success of the primary endodontic treatment, regeneration, and only cleaning and shaping in necrotic mature first premolars with apical periodontitis

a- Fifty four patients were enrolled and screened for eligibility b- Participants were randomly assigned to three groups (n=18 per group) i- Group [CRCT]: Conventional root canal treatment (n=18) ii- Group [REP] : Regenerative endodontic treatment (REP) (n=18), cell homing technique was used , and MTA was placed 3mm into the canals , the access was sealed by light cured glass ionomer then composite iii- Group [C.S]: Only cleaning and shaping (n=18) the same steps of REP but without bleeding induction and MTA was placed 3mm into the canals , the access was sealed by light cured glass ionomer then composite

Inclusion Criteria:

• Age: 20-50 years
• Medically free
• The patient should have the upper first premolar that needs endodontic treatment with apical periodontitis
• Necrotic teeth
• Participants were willing to commit to the entire period of the trial and agreed to sign the written consent after a full explanation of the study.

Exclusion Criteria:

• Symptomatic irreversible pulpitis
• If the premolar is non restorable
• If the premolar will need a post and core
• Vertical root fracture
• Open apex
• Presence of any systemic disease or allergic reactions.
• Vulnerable group; prisoners, pregnant females, mentally ill, etc…