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| Name | Class |
|---|---|
| Army Medical Center of PLA | OTHER_GOV |
| The Second Hospital of Hebei Medical University | OTHER |
| Shanghai Donglei Brain Hospital | UNKNOWN |
| Peking University International Hospital |
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This multicenter registry study aims to clarify the incidence trends of intracranial dural arteriovenous fistulas (IDAVF) and spinal dural arteriovenous fistulas (SDAVF) in China, evaluate current treatment patterns, and establish a nationwide multicenter retrospective and prospective database. The study is designed as a multicenter retrospective and prospective observational study involving more than 60 core hospitals across seven major geographic regions of China. The retrospective phase will include patients diagnosed between February 28, 2015 and February 28, 2025, while the prospective phase will enroll patients from March 1, 2025 to March 1, 2030. Eligible participants are patients diagnosed with IDAVF or SDAVF by digital subtraction angiography (DSA). The study will analyze disease incidence and temporal trends, collect baseline demographic and clinical characteristics, and evaluate treatment outcomes including obliteration rate, recurrence rate, and clinical prognosis. The crude incidence rate per 100,000 person-years during the study period will also be calculated based on Chinese census population data. The primary endpoint is the improvement rate in modified Rankin Scale (mRS) score at 6 months after treatment. Secondary endpoints include obliteration and recurrence rates on imaging follow-up at 6 months and improvement in mRS score at 12 months after treatment. Statistical analyses will be performed using SAS 9.4 software, including descriptive analyses as well as univariate and multivariate regression analyses to identify factors associated with clinical outcomes and prognosis.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| endovascular | Procedure | This is a multicenter retrospective and prospective observational registry study of patients with intracranial dural arteriovenous fistulas (IDAVF) and spinal dural arteriovenous fistulas (SDAVF) in China. No experimental intervention will be assigned as part of the study. Diagnosis, treatment selection, and follow-up will be performed according to routine clinical practice at each participating center, including microsurgery, endovascular embolization, radiosurgery, conservative management, or combined treatment strategies when applicable. The study will collect demographic, clinical, angiographic, treatment, and follow-up outcome data to evaluate epidemiology, treatment patterns, obliteration rates, recurrence, and functional outcomes in a real-world multicenter cohort. |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in modified Rankin Scale (mRS) score at 6 months after treatment | The primary outcome measure is the proportion of patients demonstrating improvement in neurological functional status, as assessed by the modified Rankin Scale (mRS), at 6 months after treatment. Clinical outcomes will be evaluated through outpatient or telephone follow-up. | 6 months after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Angiographic obliteration and recurrence rates at 6 months after treatment | The secondary outcome measure includes angiographic obliteration and recurrence rates of intracranial or spinal dural arteriovenous fistulas at 6 months after treatment, as assessed by follow-up DSA, CTA, or MRA when available. | 6 months after treatment |
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Inclusion Criteria:
Exclusion Criteria:
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The study population consists of patients diagnosed with intracranial dural arteriovenous fistulas (IDAVF) or spinal dural arteriovenous fistulas (SDAVF) at more than 60 participating centers across seven geographic regions of China. Both retrospective and prospective cohorts will be included. Eligible patients will be identified based on digital subtraction angiography (DSA)-confirmed diagnosis and available clinical and imaging data.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xin Su, M.D | Contact | 86-18210685023 | 1258940078@qq.com | |
| Yongjie Ma, M.D | Contact | 1258940078@qq.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xuanwu Hospital | Recruiting | Beijing | 100053 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39922696 | Result | Su X, Ma Y, Song Z, Liu H, Zhang C, Pang H, Chen Y, Zhao B, Huang M, Sun L, Hu P, Li G, Hong T, Ye M, Zhang H, Zhang P. Dural arteriovenous fistula research and management in China (DREAM-INI): initial characterization and patient cohort outcomes. J Neurointerv Surg. 2026 Jan 13;18(2):332-338. doi: 10.1136/jnis-2024-023014. |
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| ID | Term |
|---|---|
| D005402 | Fistula |
| ID | Term |
|---|---|
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| OTHER |
| The Second Affiliated Hospital of Chongqing Medical University | OTHER |
| Henan Provincial People's Hospital | OTHER |
| The Second Affiliated Hospital of Kunming Medical University | OTHER |
| Deyang People's Hospital | OTHER |
| Shandong Provincial Hospital | OTHER_GOV |
| Nanfang Hospital, Southern Medical University | OTHER |
| Lanzhou University Second Hospital | OTHER |
| First Hospital of China Medical University | OTHER |
| South China Hospital Affiliated to Shenzhen University | UNKNOWN |
| Zhejiang University | OTHER |
| Guangdong Provincial Hospital of Traditional Chinese Medicine | OTHER |
| Seventh Medical Center of PLA Army General Hospital | OTHER |
| Peking University Third Hospital | OTHER |
| Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | OTHER |
| The First Affiliated Hospital of Dalian Medical University | OTHER |
| The First Hospital of Hebei Medical University | OTHER |
| Third Affiliated Hospital, Sun Yat-Sen University | OTHER |
| First Affiliated Hospital of Fujian Medical University | OTHER |
| Tianjin Huanhu Hospital | OTHER |
| The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | OTHER |
| The First Affiliated Hospital of Nanchang University | OTHER |
| The Second Affiliated Hospital of Air Force Military Medical University | OTHER |
| Linyi People's Hospital | OTHER |
| The First Hospital of Jilin University | OTHER |
| First Affiliated Hospital of Wenzhou Medical University | OTHER |
| Guangdong Provincial People's Hospital | OTHER |
| Zhongshan Hospital Affiliated to Xiamen University | UNKNOWN |
| Jiangsu Province Hospital (Department of Interventional Radiology) | UNKNOWN |
| Jining First People's Hospital | OTHER |
| Fudan University | OTHER |
| Department of Neurosurgery and Junshan Brain Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | UNKNOWN |
| The First Affiliated Hospital of Shanxi Medical University | OTHER |
| The First Affiliated Hospital of Hainan Medical University | OTHER_GOV |
| First Affiliated Hospital of Xinjiang Medical University | OTHER |
| The Central Hospital of Enshi Tujia And Miao Autonomous Prefecture | OTHER |
| The First Affiliated Hospital of USTC (Anhui Provincial Hospital) | UNKNOWN |
| The First Affiliated Hospital of Anhui Medical University | OTHER |
| The First Affiliated Hospital of Army Medical University (Southwest Hospital) | UNKNOWN |
| Gansu Provincial Hospital | OTHER |
| The First Affiliated Hospital of Air Force Medicial University | OTHER |
| Baotou Central Hospital | OTHER |
| The Affiliated Hospital of Inner Mongolia Medical University | OTHER |
| Second Affiliated Hospital of Nanchang University | OTHER |
| Queen Elizabeth Hospital, Hong Kong Special Administrative Region | UNKNOWN |
| Zhujiang Hospital | OTHER |
| Ganzhou People's Hospital, Jiangxi Province | UNKNOWN |
| Affiliated Hospital of Shandong Second Medical University | UNKNOWN |
| Qilu Hospital of Shandong University | OTHER |
| Guangdong Second Provincial General Hospital | OTHER |
| Sichuan Provincial People's Hospital | OTHER |
| Fujian Provincial Hospital Affiliated to Fuzhou University | UNKNOWN |
| General Hospital of Eastern Theater Command, Chinese People's Liberation Army | UNKNOWN |
| The First Affiliated Hospital of Zhengzhou University | OTHER |
| Second Affiliated Hospital of Xi'an Jiaotong University | OTHER |
| Guangxi Hospital of the First Affiliated Hospital, Sun Yat-sen University | UNKNOWN |
| Liaoning Provincial People's Hospital | UNKNOWN |
| The Affiliated Hospital of Qingdao University | OTHER |
| The First Affiliated Hospital with Nanjing Medical University | OTHER |
| West China Hospital | OTHER |
| Tianjin Medical University General Hospital | OTHER |
| The Third Medical Center of PLA General Hospital (Former General Hospital of the Chinese People's Armed Police Forces) | UNKNOWN |
| Peking Union Medical College Hospital | OTHER |
| First Affiliated Hospital of Harbin Medical University | OTHER |
| Wuhan Central Hospital | OTHER |
| First Affiliated Hospital of Jinan University | OTHER |
| First Affiliated Hospital Xi'an Jiaotong University | OTHER |
| Second Affiliated Hospital, School of Medicine, Zhejiang University | OTHER |
| Yichang Central People's Hospital | OTHER |
| Huashan Hospital | OTHER |
| Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | OTHER |
| Peking University First Hospital | OTHER |
| Beijing Haidian Hospital | OTHER |
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| Improvement in modified Rankin Scale (mRS) score at 12 months after treatment |
The secondary outcome measure is the proportion of patients demonstrating improvement in neurological functional status, as assessed by the modified Rankin Scale (mRS), at 12 months after treatment. Clinical outcomes will be evaluated through outpatient or telephone follow-up. |
| 12 months after treatment |