Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Beijing Tiantan Hospital | OTHER |
| Beijing Tsinghua Chang Gung Hospital | OTHER |
| Tianjin Medical University General Hospital | OTHER |
| Peking University Third Hospital |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Spinal arteriovenous fistulas (AVFs) and arteriovenous malformations (AVMs) are complex neurosurgical lesions that are very challenging to manage. Spinal vascular malformations account for 3%-4% of all intradural spinal cord mass lesions. Over the last few decades our understanding of these lesions has dramatically increased thanks to neuroimaging technology (e.g. spinal angiography and indocyanine green angiography). Various treatment modalities including conservative observation, endovascular embolization, microsurgical resection, radiation therapy, and combined therapies have been reported. The treatment for these AVMs and AVFs depends on their location, the type of malformation, the area of the spine involved, and the condition of the patient at the time of treatment. Due to the rarity of these spinal vascular lesions, reports of their management and outcomes have been limited to small series and case reports. And the rates of obliteration and outcomes are not satisfactory, especially the spinal AVMs. Spinal vascular lesions are rare but represent a formidable challenge for the treating neurosurgeon.The purpose of this study is to establish multimodality treatment mode and evaluate the anatomical cure rate and functional preservation rate.
This is a multicenter, prospective, observational, registration study. There are nine centers involved in the study. The investigators set up a more detailed classification system for spinal vascular malformations. In accordance with inclusion criteria and exclusion criteria, this cohort study will include 380 samples in the study period of three years. According to the spinal angiography, the correct diagnosis and treatment strategy will be made. The minimally invasive surgical treatment methods and new techniques will be adopted such as spinal superselective angiography, preoperative embolization, intraoperative electrophysiological monitoring, intraoperative angiography, etc. All the enrolled patients will be visited a total of four times, postoperative day 1 and postoperative day 7, followed up postoperative 3 months and 12 months. The anatomical cure rate and spinal cord function will be assessed objectively. All data will be recorded in the network database platform.
Not provided
Not provided
Not provided
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Change of the spinal cord function | American Spinal Injury Association(ASIA) Score for evaluating the spinal cord function.Indexes (ASIA score) at baseline (1 day before operation) and 12 months follow-up will be collected, then the change from preoperative to 12 months follow-up will be assessed. | 1 day before operation and 12 months postoperative |
| Measure | Description | Time Frame |
|---|---|---|
| Anatomic obliteration rate | the anatomic obliteration rate is determined by angiography 3 months post operation. | 3 months post operation |
| American Spinal Injury Association(ASIA) Score | 1 week, 3 months, 6 months, 12 months post operation |
Not provided
Inclusion Criteria:
patient diagnosed with spinal vascular diseases including
patient not received surgical or interventional treatment before
patient with normal cardiac, renal and hepatic function
patient capable of understanding the content of the patient information / Informed Consent Form
patient willing and able to participate in the registry
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
patients with spinal AVMs/AVFs
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hong Tao, MD | Contact | 86-13810000653 | hongtao.edu@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Zhang Hongqi, MD | Neurosurgical Department, Xuanwu Hospital, Beijing | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tao Hong | Recruiting | Beijing | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25028446 | Background | Lee YJ, Terbrugge KG, Saliou G, Krings T. Clinical features and outcomes of spinal cord arteriovenous malformations: comparison between nidus and fistulous types. Stroke. 2014 Sep;45(9):2606-12. doi: 10.1161/STROKEAHA.114.006087. Epub 2014 Jul 15. | |
| 25175433 | Background | Rangel-Castilla L, Russin JJ, Zaidi HA, Martinez-Del-Campo E, Park MS, Albuquerque FC, McDougall CG, Nakaji P, Spetzler RF. Contemporary management of spinal AVFs and AVMs: lessons learned from 110 cases. Neurosurg Focus. 2014 Sep;37(3):E14. doi: 10.3171/2014.7.FOCUS14236. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D020758 | Spinal Cord Vascular Diseases |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
Not provided
Not provided
| OTHER |
| Chinese PLA General Hospital | OTHER |
| Beijing Hospital | OTHER_GOV |
| General Hospital of Chinese Armed Police Forces | OTHER |
| Beijing Haidian Hospital | OTHER |
| China Rehabilitation Research Center | OTHER_GOV |
Not provided
Not provided
Not provided
| Modified Aminoff & Logue's Scale (mALS) | 1 week, 3 months, 6 months, 12 months post operation |
| Modified Denis Pain and Numbness Scale (mDPNS) | 1 week, 3 months, 6 months, 12 months post operation |
| Incidence of perioperative complications | 1 week |
| 23096418 | Background | Gross BA, Du R. Spinal glomus (type II) arteriovenous malformations: a pooled analysis of hemorrhage risk and results of intervention. Neurosurgery. 2013 Jan;72(1):25-32; discussion 32. doi: 10.1227/NEU.0b013e318276b5d3. |
| 23615108 | Background | Gross BA, Du R. Spinal pial (type IV) arteriovenous fistulae: a systematic pooled analysis of demographics, hemorrhage risk, and treatment results. Neurosurgery. 2013 Jul;73(1):141-51; discussion 151. doi: 10.1227/01.neu.0000429848.91707.73. |
| D002318 | Cardiovascular Diseases |