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This study is led by the Department of Hepatobiliary Surgery of the First Affiliated Hospital of the University of Science and Technology of China (USTC), in close collaboration with multiple participating centers nationwide. The primary objective is to establish a standardized, large-scale clinical cohort database specifically for metastatic liver cancer. By collecting comprehensive data on patient demographics, primary tumor characteristics, systemic therapies, and local interventions, this registry aims to elucidate the clinical patterns and prognostic factors of secondary liver malignancies. This database will serve as a robust platform for conducting high-quality real-world studies and advancing evidence-based clinical research in the management of metastatic liver cancer.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard of Care for Metastatic Liver Cancer | Procedure | In this observational patient registry, no specific interventional procedure is assigned by the investigators. Patients included in the database receive standard clinical management and treatments for metastatic liver cancer according to current clinical guidelines and physician's discretion. These procedures may include hepatectomy, ablation, transarterial chemoembolization (TACE), systemic chemotherapy, targeted therapy, or immunotherapy. This registry aims to evaluate the real-world effectiveness and safety of these standard interventions. |
| Measure | Description | Time Frame |
|---|---|---|
| Overall Survival | The time interval from the date of initial diagnosis (or date of enrollment/surgery) to the date of death from any cause. | Up to 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| Progression-Free Survival | Description: The time interval from the date of enrollment (or initial treatment) to the date of the first documented disease progression (local recurrence or distant metastasis) or death from any cause, whichever occurs first. | Up to 10 years |
| Treatment-Related Adverse Events |
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Inclusion Criteria:
Exclusion Criteria:
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This registry targets adult patients with histologically or radiologically confirmed metastatic liver cancer. The population encompasses patients undergoing various standard clinical management strategies, including surgical resection, local ablation, transarterial chemoembolization (TACE), and systemic therapies (chemotherapy, targeted therapy, or immunotherapy).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jizhou Wang, MD PhD | Contact | +86 13836135864 | wangjoe@ustc.edu.cn | |
| Lianxin Liu, MD PhD | Contact | +86 13845159888 | liulx@ustc.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital of Bengbu Medical University | Not yet recruiting | Bengbu | Anhui | 230001 | China |
Individual participant data will not be made publicly available due to patient privacy and ethical restrictions. However, de-identified data may be shared with researchers who provide a methodologically sound proposal and have appropriate ethical approvals, subject to the approval of the study steering committee. Requests should be directed to the corresponding author.
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| ID | Term |
|---|---|
| D008113 | Liver Neoplasms |
| D009369 | Neoplasms |
| D008107 | Liver Diseases |
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D007414 | Intestinal Neoplasms |
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| ID | Term |
|---|---|
| D059039 | Standard of Care |
| ID | Term |
|---|---|
| D019984 | Quality Indicators, Health Care |
| D011787 | Quality of Health Care |
| D006298 | Health Services Administration |
| D017530 | Health Care Quality, Access, and Evaluation |
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The incidence and severity of postoperative complications or treatment-related adverse events, graded according to the Clavien-Dindo classification (for surgical complications) or CTCAE (Common Terminology Criteria for Adverse Events) version 5.0. |
| Within 90 days post-treatment |
| The First Affiliated Hospital of USTC (Anhui Provincial Hospital) | Recruiting | Hefei | Anhui | 230001 | China |
|
| The Affiliated Hospital of Qingdao University | Recruiting | Qingdao | Shandong | 266003 | China |
|
| D005770 | Gastrointestinal Neoplasms |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |