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This longitudinal observational cohort study was designed to investigate factors that influencing the occurrence and long-term survival of patients with primary liver cancer. Basic informations and detailed diagnosis informations (AJCC/TNM stage, MELD score, Child-Pugh score, and BCLC stage) were collected by professional doctors. Clinical outcomes (death, recurrence, and metastasis) will be followed up every two years after therapy.
Primary liver cancer (PLC) is highly malignant with high mortality which is particularly popular in China. Many factors are believed to associate with the occurrence and prognosis of liver cancer. This longitudinal observational cohort study was designed to investigate factors that influencing the occurrence and long-term survival of patients with primary liver cancer.
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| Measure | Description | Time Frame |
|---|---|---|
| Time of Death | The exact death time of each participants will be checked in the government medical records system | Up to 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| Time of recurrence | Time of recurrence will be obtained by telephone interview or medical treatment records | From date of diagnosis until the date of cancer recurrence or date of death from any cause, whichever came first, assessed up to 10 years |
| Time of metastasis |
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Inclusion Criteria:
Exclusion Criteria:
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Patients of this study were invited from Sun Yat-sen University Cancer Center as soon as they were diagnosed as primary liver cancer
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhu Huilian, Professor | Contact | +86 20 87331811 | zhuhl@mail.sysu.edu.cn | |
| Fang Aiping | Contact | 020-87335875 | 504 | fangaip@mail.sysu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Zhu Huilian, Professor | Sun Yat-sen University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sun Yat-sen University Cancer Center | Recruiting | Guangzhou | Guangdong | 510000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32256673 | Derived | Liu ZY, Yishake D, Fang AP, Zhang DM, Liao GC, Tan XY, Zhang YJ, Zhu HL. Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study. Nutr Metab (Lond). 2020 Mar 30;17:25. doi: 10.1186/s12986-020-00445-z. eCollection 2020. | |
| 30479648 | Derived | Liu ZY, Tan XY, Li QJ, Liao GC, Fang AP, Zhang DM, Chen PY, Wang XY, Luo Y, Long JA, Zhong RH, Zhu HL. Trimethylamine N-oxide, a gut microbiota-dependent metabolite of choline, is positively associated with the risk of primary liver cancer: a case-control study. Nutr Metab (Lond). 2018 Nov 20;15:81. doi: 10.1186/s12986-018-0319-2. eCollection 2018. |
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| ID | Term |
|---|---|
| D006528 | Carcinoma, Hepatocellular |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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Blood and liver tissue were retented during therapy
Time of metastasis will be obtained by telephone interview or medical treatment records |
| From date of diagnosis until the date of cancer metastasis or date of death from any cause, whichever came first, assessed up to 10 years |
| D009369 | Neoplasms |
| D008113 | Liver Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D008107 | Liver Diseases |