The Impact of Blood Pressure Variability During the Induc... | NCT07602465

Studies
The Impact of Blood Pressure Variability During the Induction and Surgical Periods on Postoperative Acute Kidney Injury

NCT07602465

Sponsor

Zhongda Hospital

Status

Not yet recruiting

Last Update Posted

May 27, 2026Actual

Enrollment

5,000Estimated

Phase

Not provided

Conditions

Acute Kidney Injury (AKI)

Interventions

Not provided

Countries

Not provided

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

May 2026

Overall Recruitment Status or Expanded Access Status

Not yet recruiting

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Jun 1, 2026Estimated

Primary Completion Date

Dec 1, 2026Estimated

Completion Date

Dec 1, 2026Estimated

First Submitted Date

May 15, 2026

First Submission Date that Met QC Criteria

May 15, 2026

First Posted Date

May 22, 2026Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

May 21, 2026

Last Update Posted Date

May 27, 2026Actual

Name	Class
Nanjing First Hospital, Nanjing Medical University	OTHER
The First Affiliated Hospital of Anhui Medical University	OTHER

Oversight Module

Has Data Monitoring Committee (DMC)

Yes

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Not provided

FDAAA801 Violation

Not provided

Description Module

Brief Summary

The goal of this multicenter retrospective cohort study aimed to explore the effect of BPV during anesthesia induction and surgery on the occurrence of postoperative AKI in non-cardiac surgery patients.

Detailed Description

Not provided

Design Module

Study Type

Observational

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Target Follow-Up Duration

Not provided

Phases

Not provided

Interventional Study Design

Allocation

Not provided

Intervention Model

Biospecimen

No data available

No data is available for this block.

Enrollment

5,000Estimated

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
HH		High induction blood pressure variability + High surgery blood pressure variability
HL		High induction blood pressure variability + Low surgery blood pressure variability
LH		Low induction blood pressure variability + High surgery blood pressure variability
LL		Low induction blood pressure variability + Low surgery blood pressure variability

Interventions

Not provided

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
AKI	AKI diagnosed according to KDIGO criteria within 7 days after surgery was the primary outcome event.	Within 7 days after surgery.

Secondary Outcomes

Not provided

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Undergoing non-cardiac surgery；
Adult；

Exclusion Criteria:

Undergoing urological surgeries that partially directly affect kidney function (including relief of urinary tract obstruction, nephrectomy, or kidney transplantation);
Surgery duration less than 60 minutes;
Weight < 30 kg or BMI > 35 kg/m2;
Patients who underwent reoperation within 7 days after surgery;
Surgeries not performed under general anesthesia;
ASA > IV;
No serum creatinine measurement available within 6 months before surgery (baseline value) or within 7 days after surgery;
Preexisting renal dysfunction or a diagnosis of chronic kidney disease before surgery (creatinine > 443 μmol/L);
No invasive blood pressure monitoring during the anesthesia induction period, or missing more than 25% of intraoperative invasive blood pressure data collection.

Accepts Healthy Volunteers

Not provided

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

Not provided

Standard Ages

AdultOlder Adult

Study Population

Southeast University Zhongda Hospital (2013-2024), Nanjing First Hospital (2016-2024), and the First Affiliated Hospital of Anhui Medical University (2013-2023)

Sampling Method

Non-Probability Sample

Name	Role	Phone	Extension	Email
Lingjue Chen	Contact	+86 18851656227		760026195@qq.com

IPD Sharing Statement Module

Plan to Share IPD

Description

Not provided

Types

Not provided

Time Frame

Not provided

Access Criteria

Not provided

URL

Not provided

Condition Browse Module

MeSH Terms

ID	Term
D058186	Acute Kidney Injury

Ancestor Terms

ID	Term
D051437	Renal Insufficiency
D007674	Kidney Diseases
D014570	Urologic Diseases
D052776	Female Urogenital Diseases

Browse Leaves

Not provided

Browse Branches

Not provided