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| ID | Type | Description | Link |
|---|---|---|---|
| 2025-A02135-4 | Other Identifier | INSTITUT DE CANCEROLOGIE DE L'OUEST |
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The incidence of breast cancer is increasing, particularly among young women. Cancers in young women are associated with a poor prognosis. The causes remain poorly understood.
Among young patients, some are nulliparous and others have reported cancer during or after pregnancy. Preliminary studies suggest that breast tissue remodeling associated with pregnancy may influence the emergence and aggressiveness of early-onset cancers. However, breastfeeding and pregnancy are described as protective factors against the onset of breast cancer. The precise biology depending on age and the time between pregnancy and breast cancer is still poorly understood.
The aim of our study is to increase our knowledge of cancer in young women and its potential links to pregnancy and breastfeeding. Information on the contraceptive habits and pregnancies of the patients in the study will be collected, and molecular and cellular analyses will be performed on frozen tumor samples as well as samples fixed and embedded in paraffin.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient aged ≤ 45 years at diagnosis Triple-negative breast cancer |
| ||
| Patient aged ≤ 45 years at diagnosis RH+ breast cancer |
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| Patient aged ≥ 55 years at diagnosis Triple-negative breast cancer |
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| Patient aged ≥ 55 years at diagnosis RH+ breast cancer |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No Intervention: Observational Cohort | Other | No intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| event-free survival | event-free survival (time between diagnosis and the occurrence of the first event among the following: local recurrence, metastatic recurrence, death) | up to 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Describe the association between age at diagnosis and event-free survival (EFS) and overall survival. | Describe the association between age at diagnosis and event-free survival (EFS) and overall survival (time between diagnosis and death from all causes. Two overall survival rates will be calculated from two data sources: ICO data and INSEE data) | up to 5 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with triple-negative (TN) or RH+ breast cancer treated at the ICO who were ≤ 45 years old or ≥ 55 years old at the time of diagnosis.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marie ROBERT, MD | Contact | +33240679900 | marie.robert@ico.unicancer.fr | |
| Vincent GUEN, Ph D | Contact | + 33 2 28 08 02 89 | Vincent.Guen@univ-nantes.fr |
| Name | Affiliation | Role |
|---|---|---|
| Marie ROBERT, MD | INSTITUT DE CANCEROLOGIE DE L'OUEST | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut de Cancerologie de L'Ouest | Saint-Herblain | 44800 | France |
The anonymized individual participant data used in the primary analysis of the study will be made available. This includes the main manuscript and its supplementary materials (texts, tables, figures, and appendices).
The data will be accessible from 6 months after the publication of the main article, and for up to 3 years after this publication.
Access will be granted to researchers submitting a methodologically sound proposal that does not duplicate the secondary analyses planned by the research team.
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Diagnostic frozen tumor samples and FFPE tissue sections
| Describe the association between previous pregnancy and overall survival according to age at diagnosis (≤45 years or ≥55 years). | Describe the association between previous pregnancy and overall survival according to age at diagnosis (≤45 years or ≥55 years). (Overall survival: time between diagnosis and death from all causes. Two overall survival rates will be calculated from two data sources: ICO data and INSEE data) | Up to 5 years |
| Describe the association between breastfeeding and EFS/overall survival in nulliparous women according to age at diagnosis (≤45 years or ≥55 years). | Describe the association between breastfeeding and EFS/overall survival in nulliparous women according to age at diagnosis (≤45 years or ≥55 years).(Overall survival: time between diagnosis and death from all causes. Two overall survival rates will be calculated from two data sources: ICO data and INSEE data) | Up to 5 years |
| Describe the association between age at first pregnancy (≥35 years, ≤35 years, nulliparity) and EFS/overall survival according to age at diagnosis (≤45 years or ≥55 years). | Describe the association between age at first pregnancy (≥35 years, ≤35 years, nulliparity) and EFS/overall survival according to age at diagnosis (≤45 years or ≥55 years).(Overall survival: time between diagnosis and death from all causes. Two overall survival rates will be calculated from two data sources: ICO data and INSEE data) | Up to 5 years |
| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| D001942 | Breast Feeding |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D005247 | Feeding Behavior |
| D001519 | Behavior |
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