Gingival TrxR1 Expression in Periodontal Health and Periodontitis

Thioredoxin Reductase 1 Levels in Gingival Tissue as an Oxidative Stress Biomarker in Periodontitis

This study aims to investigate the role of the thioredoxin system in the development and progression of periodontitis. Researchers will examine the levels of specific antioxidant markers, such as thioredoxin reductase 1 (TrxR1), glutathione (GSH), and malondialdehyde (MDA), in gingival tissue samples collected from healthy individuals and patients with different stages of periodontal disease. The goal is to determine if TrxR1 levels can serve as a potential biomarker for diagnosing the severity and activity of periodontitis.

Inclusion Criteria:

• Being between the ages of 18 and 70.
• Having no known systemic disease.
• Non-smokers.
• No history of medication or supplement use in the last 3 months.
• For the Periodontitis groups: Interdental clinical attachment loss (CAL), probing pocket depth (PPD), and radiographic bone loss according to 2017 World Workshop criteria.

Exclusion Criteria:

• Smoking.
• Pregnancy or breastfeeding.
• Presence of a systemic disease (e.g., diabetes mellitus, hypertension, rheumatoid arthritis, cancer, thyroid disorders, kidney or lung diseases).
• History of any periodontal surgical procedure within the last 6 months.
• Use of medication or supplements within the last 3 months.