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| ID | Type | Description | Link |
|---|---|---|---|
| KU-IRB-2026-1-2 | Other Identifier | Ethics committee number |
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movement using low-level laser therapy with different wavelengths. Participants will receive laser application during orthodontic treatment, and the rate of canine movement will be measured and compared between the study groups. The results may help determine whether low-level laser therapy can accelerate orthodontic tooth movement safely and effectively.
Photobiomodulation therapy (PBMT) has been proposed as a non-invasive adjunctive method to accelerate orthodontic tooth movement and reduce overall treatment duration. This split-mouth randomized clinical trial aims to evaluate and compare the effectiveness of two different laser wavelengths (650 nm and 976 nm) on the acceleration of maxillary canine movement during orthodontic treatment.
Participants requiring bilateral maxillary first premolar extraction and canine retraction as part of their orthodontic treatment will be included. Each patient will serve as their own control using a split-mouth design. One side will receive PBMT application during canine retraction, while the contralateral side will act as the control or receive an alternative wavelength according to the randomization protocol.
Orthodontic canine movement will be performed using standardized orthodontic mechanics under controlled force application. The primary outcome measure will be the rate of maxillary canine movement assessed at regular intervals. Secondary outcomes will include total treatment duration required for space closure and the influence of patient-related factors such as age and gender on treatment outcomes.
The study will compare the clinical effectiveness of 650 nm and 976 nm wavelengths in accelerating orthodontic tooth movement. Statistical analyses including paired t-tests, independent t-tests, and correlation analyses will be used to evaluate differences between groups and assess associations between demographic variables and treatment response.
The findings of this study may provide clinically relevant evidence regarding the effectiveness of PBMT in reducing orthodontic treatment time and improving treatment efficiency.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 650 nm PBMT | Experimental | Participants receive photobiomodulation therapy using a 650 nm laser during maxillary canine retraction. |
|
| 976 nm PBMT | Experimental | Participants receive photobiomodulation therapy using a 976 nm laser during maxillary canine retraction. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 650 nm Photobiomodulation Therapy | Device | Application of 650 nm low-level laser therapy during maxillary canine retraction to accelerate orthodontic tooth movement. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rate of Maxillary Canine Movement | Measurement of the amount of maxillary canine movement during orthodontic retraction following application of photobiomodulation therapy using 650 nm and 976 nm wavelengths. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation Between Age and Rate of Canine Retraction | Assessment of the correlation between patient age (years) and rate of maxillary canine retraction measured in millimeters per month using digital caliper measurements on study models. | 6 months |
| Difference in Rate of Canine Retraction Between Sexes |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Orthodontic Clinic, College of Dentistry, University of Kufa | Najaf | Najaf Governorate | 54001 | Iraq |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | Alhumadi A. Gender-related response to different wavelength low-level laser therapy in orthodontic mandibular canine movement: a split-mouth study. Endodontics Today. 2026;24:58-66. doi:10.36377/ET-0159. | ||
| Background | Al-Kufi HM, Alhumadi A, Huthiafa SM. A comparative evaluation of postoperative re-pigmentation following gingival depigmentation using a 940-nm diode laser and abrasion method: a split-mouth study. Lasers in Dental Science. 2024;8(1):3. doi:10.1007/s41547-023-00208-y. | ||
| 34182967 | Background | Zheng J, Yang K. Clinical research: low-level laser therapy in accelerating orthodontic tooth movement. BMC Oral Health. 2021 Jun 28;21(1):324. doi: 10.1186/s12903-021-01684-z. | |
| 36464569 |
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Individual participant data will not be publicly shared in order to protect participant confidentiality and privacy.
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This study uses a split-mouth randomized clinical trial design in which each participant serves as their own control. Maxillary canine retraction will be performed bilaterally following premolar extraction. Different photobiomodulation therapy wavelengths (650 nm and 976 nm) will be applied according to the randomization protocol during orthodontic canine movement.
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This is an open-label study in which both the investigator and participants are aware of the laser wavelength applied during treatment.
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| 976 nm Photobiomodulation Therapy | Device | Application of 976 nm low-level laser therapy during maxillary canine retraction to accelerate orthodontic tooth movement. |
|
Comparison of the rate of maxillary canine retraction (mm/month) between male and female participants measured using digital caliper measurements on study models. |
| 6 months |
| Background |
| Wazwaz F, Seehra J, Carpenter GH, Papageorgiou SN, Cobourne MT. Duration of canine retraction with fixed appliances: A systematic review and meta-analysis. Am J Orthod Dentofacial Orthop. 2023 Feb;163(2):154-172. doi: 10.1016/j.ajodo.2022.08.009. Epub 2022 Dec 1. |
| ID | Term |
|---|---|
| D028022 | Low-Level Light Therapy |
| ID | Term |
|---|---|
| D053685 | Laser Therapy |
| D013812 | Therapeutics |
| D010789 | Phototherapy |
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