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Gingival recession (GR) is a term that describes the displacement of the gingival margin apical to the cemento-enamel junction (CEJ) of a tooth. The gold standard of GR treatment is surgical coverage through coronally advanced flap with subepithelial connective tissue graft (CAF+SCTG) (3). But, the need for a non-invasive technique for managing GR has not been frequently addressed.
Phenytoin (PHT), used as an anti-seizure medication, has an established side effect of causing drug-influenced gingival enlargement. Its stimulatory effects on soft tissue metabolism suggested PHT to be tested topically for its effectiveness in wound healing. However, none of the previous studies that investigated topical phenytoin has assessed gingival recession; except for a case series.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Phenytoin | Active Comparator |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| phenytoin cream | Drug | Phenytoin 1% paste |
| |
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical Attachment loss | measured by Periodontal probe (distance from cemento-enamel junction to base of the pocket) | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| gingival recession | Measured by periodontal probe (distance from gingival margin to cemento-enamel junction) | 3 months |
| probing depth | Measured by periodontal probe (distance from gingival margin to base of the pocket) |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D005889 | Gingival Recession |
| ID | Term |
|---|---|
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| Other |
placebo paste |
|
| 3 months |
| gingival thickness | Measured by periodontal probe (is the probe visible during probing or not? Yes/No) | 3 months |
| Keratinized tissue width | Measured by periodontal probe | 3 months |
| dentin hypersensitivity | assessed by asking the patient if they feel sensitivity as binary outcome (yeas/no) and if yes, it is assessed by VAS | 3 months |
| D055093 |
| Periodontal Atrophy |