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The aim of this study was to evaluate the effect of two root-conditioning agents used in conjunction with subepithelial connective graft technique on root coverage outcomes. One is citric acid plus tetracycline and the other is antimicrobial photodynamic therapy.
Citric acid plus tetracycline has properties of root surface decontamination, surface demineralization and exposure of collagen fibers.
Antimicrobial photodynamic therapy has been widely used in Periodontics to obtain reduction of periodontopathogenic bacteria with absence of systemic side effects and minimal bacterial resistance. Also, it has properties of root demineralization and exposure of collagen fibers. These properties may enhance root coverage in procedures of subepithelial connective graft.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Active Comparator | Root treatment with scaling and root planing. |
|
| Citric acid plus tetracycline | Experimental | Root treatment with 50% citric acid plus 10% tetracycline, pH1, passive application for 90s. |
|
| Antimicrobial photodynamic therapy | Experimental | Antimicrobial photodynamic therapy with toluidine blue O (100ug/ml - 60s pre-irradiation - pH4) and red laser (660nm, 30 milliwatts, 45 joules per square centimeter, sweeping mode, 90s) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control | Procedure | Periodontal plastic surgery aiming root coverage by palatal connective tissue graft. Root treatment with scaling and root planing |
|
| Measure | Description | Time Frame |
|---|---|---|
| Total root coverage measured with a periodontal probe in mm | Distance from cemento-enamel junction to gingival margin = 0 mm | one year |
| Measure | Description | Time Frame |
|---|---|---|
| Keratinized mucosa width measured with a periodontal probe in mm | Ideal if keratinized mucosa width > 5mm | one year |
| Dentin hypersensitivity measured by applying an air jet on teeth and patient fills up a visual analogue scale |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bauru School of Dentistry | Bauru | São Paulo | 17012-901 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26358636 | Background | Damante CA, Ducati P, Ferreira R, Salmeron S, Zangrando MSR, de Rezende MLR, Sant'Ana ACP, Greghi SLA, Magalhaes AC. In vitro evaluation of adhesion/proliferation of human gingival fibroblasts on demineralized root surfaces by toluidine blue O in antimicrobial photodynamic therapy. Photodiagnosis Photodyn Ther. 2016 Mar;13:303-307. doi: 10.1016/j.pdpdt.2015.08.009. Epub 2015 Sep 7. | |
| 26095265 |
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| ID | Term |
|---|---|
| D005889 | Gingival Recession |
| ID | Term |
|---|---|
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D019343 | Citric Acid |
| D013752 | Tetracycline |
| ID | Term |
|---|---|
| D002951 | Citrates |
| D014233 | Tricarboxylic Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
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Interventions in different patients
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The outcome assessor did not have access to patient's records
| citric acid plus tetracycline | Procedure | Periodontal plastic surgery aiming root coverage by palatal connective tissue graft. Root treatment with citric acid plus tetracycline |
|
| antimicrobial photodynamic therapy | Procedure | Periodontal plastic surgery aiming root coverage by palatal connective tissue graft. Root treatment with antimicrobial photodynamic therapy |
|
Ideal if scale = 0
| one year |
| Background |
| Karam PS, Sant'Ana AC, de Rezende ML, Greghi SL, Damante CA, Zangrando MS. Root surface modifiers and subepithelial connective tissue graft for treatment of gingival recessions: a systematic review. J Periodontal Res. 2016 Apr;51(2):175-85. doi: 10.1111/jre.12296. Epub 2015 Jun 11. |
| D055093 |
| Periodontal Atrophy |
| D009930 |
| Organic Chemicals |
| D013754 | Tetracyclines |
| D009279 | Naphthacenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D011083 | Polycyclic Compounds |