Clinical Utility of Preoperative Thyroid GuidePx® Testing

Clinical Utility of Preoperative Thyroid GuidePx® Testing

The purpose of this study is to learn whether having Thyroid GuidePx® test results available before treatment may help patients with papillary thyroid cancer and doctors make better-informed treatment decisions.

Inclusion Criteria:

• Patients aged 18 years or older at the time of enrollment
• English-speaking
• Bethesda V or VI cytology following FNA of a thyroid nodule (papillary thyroid cancer)
• Bethesda III or IV with ThyroSpec positive for BRAFV600E, TERT, rearrangements in BRAF, RET, NTRK1, NTRK3, RAS + TERT, RAS + EIF1AX, AKT1, PI3CA, CTNNB1, EGFR, rearrangements in ALK
• Tumor 1- 4cm in size
• No lymph node involvement on ultrasound
• No gross extrathyroidal extension on ultrasound

Exclusion Criteria:

• Prior thyroid operation
• Distant metastatic disease
• Personal history of thyroid cancer
• History of whole-body radiation exposure or radiation to the head and neck region