Molecular Testing to Direct Extent of Initial Thyroid Surgery

Molecular Testing to Direct Extent of Initial Thyroid Surgery

The research study consists of the participant agreeing to 1) the use of preoperative molecular testing (ThyroSeq) to guide extent of initial surgery and 2) the prospective collection of medical record data related to treatment of thyroid cancer.

The aim of the proposed pilot study is to use a clinical algorithm that incorporates molecular, clinical and radiographic factors to inform surgical management. This study is the first to propose molecular-directed surgical management for this commonly diagnosed cancer.

Inclusion Criteria:

• Thyroid nodule is >1.5 cm
• Preoperative FNA biopsy that is positive for papillary thyroid cancer or suspicious for papillary thyroid cancer

Exclusion Criteria:

• Prior thyroid/parathyroid surgery
• Clinical indications for total thyroidectomy including hypothyroidism, history of head or neck radiation when <18 years old
• Recurrent laryngeal nerve dysfunction
• Diagnosis of concurrent primary hyperparathyroidism