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| Name | Class |
|---|---|
| King Fahad Specialist Hospital Dammam | OTHER |
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Unilateral spastic cerebral palsy (USCP) is the most common subtype of cerebral palsy and significantly limits upper limb function. Traditional therapies such as constraint-induced movement therapy (CIMT) and bimanual intensive training offer limited benefits. Pharmacologic treatments often produce behavioral side effects and do not address underlying neuro-plastic deficits. There is an unmet need for safe, effective, non-invasive interventions targeting motor recovery through cortical modulation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anodal tDCS | Active Comparator | 5 sessions of 20-minute anodal tDCS over the affected motor cortex Concurrent 20-minute therapist-guided bimanual training Standardized protocol for stimulation site and parameters Sessions spread over 1-2 weeks (with 1-week buffer for make-up) |
|
| Sham tDCS | Sham Comparator | 5 sessions of 20-minute sham tDCS over the affected motor cortex Concurrent 20-minute therapist-guided bimanual training Standardized protocol for stimulation site and parameters Sessions spread over 1-2 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Anodal tDCS | Other | Anodal tDCS will be applied to the affected motor cortex area for 20 minutes along with the bimanual motor training. The intervention will be applied for 5 days in 1-2 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| ABILHAND-KIDS | ABILHAND-Kids is used to measure a child's manual ability (using their hands/arms) for daily tasks, especially for children with conditions like cerebral palsy or brachial plexus birth injury. | baseline, after 1 week of intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Box and Block test | The Box and Block Test (BBT) assesses gross manual dexterity in kids with Cerebral Palsy (CP) aged 6-15 by having them move as many 1-inch blocks as possible from one box side to another in 60 seconds, one block at a time, testing each hand separately | Baseline, after 1 week of intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mirza Obaid Baig Assistant Professor, MS | Contact | 00923332238706 | obaid.baig@riphah.edu.pk |
| Name | Affiliation | Role |
|---|---|---|
| Mirza Obaid Baig, MS | Riphah International University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pakistan Railway Hospital | Rawalpindi | Punjab Province | Pakistan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30733800 | Background | Inguaggiato E, Bolognini N, Fiori S, Cioni G. Transcranial Direct Current Stimulation (tDCS) in Unilateral Cerebral Palsy: A Pilot Study of Motor Effect. Neural Plast. 2019 Jan 15;2019:2184398. doi: 10.1155/2019/2184398. |
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| ID | Term |
|---|---|
| D002547 | Cerebral Palsy |
| D009128 | Muscle Spasticity |
| ID | Term |
|---|---|
| D001925 | Brain Damage, Chronic |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| Sham tDCS | Other | Sham tDCS will be applied to the affected motor cortex for 20 minutes along with the bimanual motor training. The intervention will be applied for 5 days in 1-2 weeks. |
|
| Movement-related cortical potentials |
Movement-related cortical potentials (MRCP) with the help of EEG: peak amplitude, onset latency, and area under the curve at Cz/C3/C4. |
| baseline, 1 week after intervention |
| Event-related desynchronization (ERD) / synchronization (ERS) | Event-related desynchronization (ERD) / synchronization (ERS) with the help of EEG: mu (8-13 Hz) and beta (13-30 Hz) ERD magnitude and timing during movement. | baseline, 1 week after intervention |
| Resting-state sensorimotor beta/mu power | Resting-state sensorimotor beta/mu power with the help of EEG: absolute and relative power at C3/C4 and central ROI. | baseline, 1 week after intervention |
| NIH Toolbox Cognitive and Emotional Scores | The NIH Toolbox for the Assessment of Neurological and Behavioral Function (NIH Toolbox) is a set of standardized measures used by researchers and clinicians to assess motor, cognitive, emotional, and sensory functions. | baseline, 1 week after intervention |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D009122 | Muscle Hypertonia |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |