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This clinical trial aims to investigate whether transcranial electrical stimulation (tDCS) combined with transcranial magnetic stimulation(TMS) has an impact on the cognitive and motor functions of stroke patients, and to evaluate the safety of this protocol. The main objective is to answer the following question: Can electromagnetic combined stimulation of the left Dorsolateral prefrontal lobe(DLPFC) improve the performance of working memory, motor function and cognitively motor dual tasks in stroke patients? What is its mechanism of action? Participants will undergo a combined real or sham electromagnetic stimulation of 20 minutes of tDCS and 40 seconds of TMS once a day for 7 days. Researchers will compare the effects of real stimulation with sham stimulation to see if the real stimulation can bring better results to patients. Clinical evaluations (cognitive and motor scales) and functional Near-Infrared Spectroscopy(fNIRS) were conducted before and after stimulation to record relevant brain activities
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| real tDCS-TMS | Experimental |
| |
| sham tDCS-TMS | Sham Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| occupational therapy | Behavioral | occupational therapy 1 hour a day for 7 days |
|
| Measure | Description | Time Frame |
|---|---|---|
| n-back task accuracy rate | n-back task record accuracy rate | Baseline and 7-days |
| n-back task reaction time | n-back task record reaction time | Baseline and 7-days |
| functional connectivity during n-back task | n-back task with fNIRS to record Oxy-Hb concentration | Baseline and 7-days |
| Verbal fluency test(VFT)accuracy rate | VFT task record accuracy rate | Baseline and 7-days |
| Verbal fluency test(VFT)reaction time | VFT task record reaction time | Baseline and 7-days |
| functional connectivity during Verbal fluency test(VFT) | VFT task with fNIRS to record Oxy-Hb concentration | Baseline and 7-days |
| Measure | Description | Time Frame |
|---|---|---|
| Montreal Cognitive Assessment(MoCA) | MoCA scale(score 0-30, the higher score means the better function) | Baseline and 7-days |
| isokinetic muscle strength test | isokinetic muscle strength test of knee |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jingting Li | Contact | +86 13560365827 | lijt53@mail.sysu.edu.cn | |
| Hanjun Liu | Contact | +86 15920175118 | lhanjun@mail.sysu.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University | Guangzhou | Guangdong | China |
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year 2028 data will become available and for 5 years
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| ID | Term |
|---|---|
| D020521 | Stroke |
| D003072 | Cognition Disorders |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D009788 | Occupational Therapy |
| ID | Term |
|---|---|
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
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| real tDCS | Other | real 20 minutes of tDCS once a day for 7 days |
|
| sham tDCS | Other | sham 20 minutes of tDCS once a day for 7 days |
|
| real TMS | Other | 40 seconds of real TMS once a day for 7 days |
|
| sham TMS | Other | 40 seconds of sham TMS once a day for 7 days |
|
| Baseline and 7-days |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D013812 |
| Therapeutics |