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The aim of this randomized controlled study is to compare the efficacy of three successive doses of a GnRH agonist ( administered 36 , 24 and 12 hours before oocyte retrieval ) with a single dose of a GnRH agonist ( administered 36 hours before oocyte retrieval ) in triggering ovulation in hyper-responders
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Successive doses GnRH agonist | Experimental | Three successive doses of GnRH agonist are administered 36 , 24 and 12 hours before oocyte retrieval |
|
| Single dose GnRH agonist | Active Comparator | A single dose of GnRH agonist is administered 36 hours before oocyte retrieval |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Successive doses GnRH agonist | Drug | GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) is administered 36 hours before ovum pickup. Two additional doses of triptorelin ( 0.1 mg / S.C ) are administered subcutaneously 12 and 24 hours after the first dose of GnRH agonist. |
| Measure | Description | Time Frame |
|---|---|---|
| Metaphase-II oocytes rate | Number of MII oocyte/ number of cumulus oocyte complex | Ten to fifteen days after starting ovarian stimulation |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical pregnancy rate | Presence of intrauterine gestational sac detected by transvaginal ultrasound | Five weeks after embryo transfer |
| Ongoing pregnancy Rate | Pregnancies continued beyond 20 weeks gestation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Usama M. Fouda, Prof. | Contact | +201095401375 | umfrfouda@yahoo.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bedaya Hospital | Giza | Egypt |
|
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39033370 | Background | Hashemi SH, Hafezi M, Arabipoor A, Zareei M, Vesali S, Eftekhari-Yazdi P. Can We Harvest More Mature Oocytes by Repeating Gonadotropin-Releasing Hormone Agonist Doses in Polycystic Ovarian Syndrome Patients at Risk of OHSS in Antagonist Cycles? A Randomised Clinical Trial. Int J Fertil Steril. 2024 Jul 13;18(Suppl 1):48-54. doi: 10.22074/ijfs.2023.2008905.1513. |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D007987 | Gonadotropin-Releasing Hormone |
| ID | Term |
|---|---|
| D010906 | Pituitary Hormone-Releasing Hormones |
| D007028 | Hypothalamic Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
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| Single dose GnRH agonist | Drug | GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) is administered 36 hours before ovum pickup. |
|
| Eighteen weeks after embryo transfer |
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D009479 | Neuropeptides |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D009842 | Oligopeptides |
| D009419 | Nerve Tissue Proteins |
| D011506 | Proteins |