Cell-based Non-invasive Prenatal Test Workflow

Prospective Collection of Maternal Venous Blood Samples for Cell-based Non- Invasive Prenatal Test Workflow

The aim of this study is to optimize a new non-invasive prenatal screening method based on the capture of fetal cells from maternal blood and to complete its development by obtaining maternal blood samples during the first trimester of pregnancy.

Inclusion Criteria:

1. Informed consent signed before any study-specific procedures
2. Pregnant women with singleton or twin pregnancy, at 8+0 - 14+6 week of gestation, aged ≥18 years
3. No medical contraindication for collecting 30 ml blood sample

Exclusion Criteria:

1. Unable to provide informed consent
2. Known infections that carry a risk of vertical transmission
3. Known maternal viral diseases: HIV and HCV, HBV