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Portal vein thrombosis (PVT) is a common complication in patients with liver cirrhosis and is associated with increased morbidity due to worsening portal hypertension and hepatic decompensation. The clinical presentation and radiological patterns of PVT vary widely, and the factors predicting its development remain incompletely understood.
This observational study will include adult patients (≥18 years) with established liver cirrhosis who are admitted to the Department of Gastroenterology and Tropical Medicine, Al-Rajhi Liver Hospital, Assiut University. Eligible participants will undergo routine screening for PVT using Doppler ultrasonography, with confirmation by contrast-enhanced computed tomography when indicated.
The study aims to evaluate the clinical characteristics, laboratory parameters, and radiological features of PVT. Cases of PVT will be classified according to extent (partial or complete) and anatomical location (main portal vein, right branch, left branch, or combined involvement). Clinical and laboratory data will be analyzed to identify potential predictors associated with the development and severity of PVT.
The findings of this study are expected to improve understanding of the risk factors and radiological patterns of PVT in cirrhotic patients, contributing to better risk stratification and clinical management.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 (Patients): with PVT, Group 2 (Controls): without PVT |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Abdominal US, Doppler US and abdominal multi-slice computed tomography (MSCT) with contrast was performed | Diagnostic Test | to assess portal circulation, portosystemic collaterals, the presence of PVT, ascites and HCC. |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of Portal Vein Thrombosis (PVT) | Proportion of cirrhotic patients diagnosed with portal vein thrombosis based on Doppler ultrasonography with confirmation by contrast-enhanced CT when indicated. | At baseline (during study enrollment period) |
| Predictors of Portal Vein Thrombosis | Identification of clinical, laboratory, and radiological factors associated with the presence of PVT in cirrhotic patients | Baseline assessment |
| Measure | Description | Time Frame |
|---|---|---|
| Radiological Pattern of PVT | Distribution of portal vein thrombosis according to: Extent (partial vs complete) Anatomical location (main portal vein, right branch, left branch, or combined involvement) | At time of PVT diagnosis |
| Association Between PVT Type and Clinical Parameters |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients with liver cirrhosis
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assiut University Hospital | Asyut | 71515 | Egypt |
I do not have specific consent from participants to share individual-level data.
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Correlation between type of PVT (partial vs complete) and clinical/laboratory characteristics of patients. |
| At time of diagnosis |
| ID | Term |
|---|---|
| D008103 | Liver Cirrhosis |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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