Portal Vein Thrombosis in Cirrhosis

Portal Vein Thrombosis in Cirrhosis: A Cohort Sudy

This study evaluates the supervivence of cirrhotic patients that develop portal vein thrombosis in comparison to cirrhotic patients that do not develop portal vein thrombosis.

Patients newly diagnosed with portal vein thrombosis by imaging tests, that evaluate the extent and exclude tumoral origin, will be included (informed consent previously signed).

Anticoagulant treatment will be initiated according to clinical guidelines (if there is no contraindication) first with LMWH (low molecular weight heparin) and later with dicoumarin.

An abdominal CT will be performed to evaluate the extent and exclude tumoral origin; a gastroscopy to evaluate portal hypertension (and do prophylaxis if required) and thrombophilia study.

Patients will be followed by imaging and laboratory tests every 6 months; to evaluate the response to the treatment and detect any cirrhosis complication.

Inclusion Criteria:

• Cirrhosis diagnosed by liver biopsy or non-invasive methods/clinical, analytics or ultrasound usual criteria
• Portal vein thrombosis of newly diagnosed (defined as partial or complete obstruction of splenoportal vessels objectified by imaging with/without symptomatology) ≤ 6 months.
• Over 18 years old
• Want to participate (informed consent)

Exclusion Criteria:

• Pregnant or lactating
• Patients with tumoral vein thrombosis or elevated alpha-fetoprotein or high suspicion of underlying neoplastic disease.
• Thrombocytopenia < 25.000 .
• Patients with cavernomatosis or portal vein thrombosis already known.
• Patient refusal to participate
• Patients already treated with anticoagulants for other diseases (atrial fibrillation, pulmonary thrombosis...)