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| ID | Type | Description | Link |
|---|---|---|---|
| TQ01000332 | Other Grant/Funding Number | Technology Agency of the Czech Republic |
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Early cognitive disorders diagnosis is becoming increasingly important due to population aging. The most common causes include Alzheimer's disease and frontotemporal dementia. These diseases are also manifested by changes in speech. NLP allows us to identify and classify these changes. The project aims to develop a web application for self-assessment and automated detection of cognitive disorders from speech. The application will have a form of a dialogue system using machine learning methods. The novelty of this approach is the possibility of an efficient self-assessment of a wide spectrum of the Czech population from their homes and an automated evaluation of test results. Early detection can be followed by a more detailed diagnosis and adequate treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group of patients with neurocognitive disorder | Experimental | The experimental group consists of patients with Mild Cognitive Impariment (MCI) and dementia. |
|
| Healthy elderly participants | Active Comparator | The control group consists of cognitively healthy elderly participants. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) | Diagnostic Test | A brief individually administered battery to measure cognitive decline or improvement across five domains in ages 12 to 89 years 11 months. |
| Measure | Description | Time Frame |
|---|---|---|
| The difference in results between groups of patients with cognitive impairment and healthy individuals in individual parts of our experimental neuropsychological battery Diagnostic Test: Digitial Diagnostics of Dementia (DDD) | Through study completion, an average of 2 years | |
| Correlation of the results of our experimental battery (DDD) with RBANS | Through study completion, an average of 2 years | |
| Correlation of the results of our experimental battery (DDD) with MAST | Through study completion, an average of 2 years | |
| Correlation of the results of our experimental battery (DDD) with ALBA | Through study completion, an average of 2 years | |
| Correlation of the results of our experimental battery (DDD) with POBAV | Through study completion, an average of 2 years |
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Inclusion Criteria for the group of healthy participants:
Inclusion Criteria for the group of patients:
- be diagnosed with mild neurocognitive impairment (MCI) or neurocognitive disorder (dementia) according to the international DSM-5 criteria
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| Name | Affiliation | Role |
|---|---|---|
| Luboš Šmídl, Ing. Ph.D. | Západočeská univerzita v Plzni / Fakulta aplikovaných věd | Study Chair |
| Jan Švec, Ing. Ph.D. | Západočeská univerzita v Plzni / Fakulta aplikovaných věd | Principal Investigator |
| Filip Polák, Ing. | Západočeská univerzita v Plzni / Fakulta aplikovaných věd | Principal Investigator |
| Aleš Bartoš, prof. MUDr. Ph.D. | Fakultní nemocnice Královské Vinohrady | Study Director |
| Martin Víta, Mgr. Ph.D. | Fyzikální ústav AV ČR, v. v. i. | Study Director |
| Marie Kompasová, Mgr. | Univerzita Karlova, Fakultní nemocnice Královské Vinohrady | Principal Investigator |
| Michaela Zapletalová, Mgr. | Univerzita Palackého, Fakultní nemocnice Královské Vinohrady | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Západočeská univerzita v Plzni / Fakulta aplikovaných věd | Pilsen | 306 14 | Czechia | |||
| Faculty Hospital Kralovske Vinohrady |
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| the Mississippi Aphasia Screening Test | Diagnostic Test | he Mississippi Aphasia Screening Test (MAST) was developed as a brief, repeatable screening measure for individuals with severely impaired communication/language skills. |
|
| Amnesia Light and Brief Assessment (ALBA) | Diagnostic Test | Very brief test used to measure deficits of more cognitive functions (short-term, episodic, semantic amnesia, sensory and motor aphasia, apraxia, psychomotor speed). |
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| The Picture naming and immediate recall test (PICNIR) | Diagnostic Test | Very brief test used to measure deficits of more cognitive functions (short-term, episodic, semantic amnesia, sensory and motor aphasia, apraxia, psychomotor speed). |
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| Geriatric Depression Scale (GDS-15) | Diagnostic Test | The Geriatric Depression Scale (GDS-15), used to screen for depression in adults aged 55 and older, consists of 15 items that assess mental health based on feelings over the past week. |
|
| The Beck Anxiety Inventory (BAI) | Diagnostic Test | A formative assessment and rating scale of anxiety. |
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| Digitial Diagnostics of Dementia (DDD) | Diagnostic Test | Our experimental screening battery developed for this study. |
|
| Prague |
| 100 00 |
| Czechia |
| Fyzikální ústav AV ČR, v. v. i. | Prague | Czechia |
| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D003704 | Dementia |
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
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