Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| King's College London | OTHER |
Not provided
Not provided
Not provided
Not provided
The primary objective of the study is to evaluate the feasibility of eliciting continuous narrative speech in different neurodegenerative and psychiatric indications, using remote, self-administered speech tasks, as measured by the average length of speech elicitation for each speech task during the first week of self-assessment. Secondary objectives include (1) evaluating the reliability of speech tasks in the remote self-administered setting, as measured by the intra- and inter-subject variance; (2) accessing the adherence of speech tasks in this setting, as measured by the subject average fraction of days during the first week, where at least one task response is submitted; (3) evaluating the feasibility of using speech tasks in the setting of a telemedicine videoconference, as measured by the average length of speech elicited in each group; (4) evaluate whether a set of acoustic and linguistic patterns can detect each indication, compare to either a control group or all other indications, as measured by the area under the receiver operating characteristic curve (AUC), sensitivity, specificity and Cohen's kappa of the relevant binary classifier; (5) evaluating how the performance of such algorithms can be impacted by speaker and environment covariates, as measured by the Kendall rank correlation coefficient of the AUC of each classifier and each of age group, gender and speech-to-reverberation modulation energy ratio.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1: Cognitive Disorders | Alzheimer's Disease (AD) Meet National Institute of Aging - Alzheimer's Association (NIA-AA) core clinical criteria (2011) for MCI due to Alzheimer's or Mild Alzheimer's Dementia Dementia with Lewy bodies (DLB) Diagnosis of possible or probable DLB based on the criteria defined by The Dementia with Lewy Bodies Consortium (2015) Non-AD non-DLB MCI Diagnosis of 'probable' and 'possible' behavioral variant frontotemporal dementia (bvFTD) according to the International Behavioral Variant FTD Criteria Consortium OR semantic variant or nonfluent-agrammatic variant primary progressive aphasia (PPA) FTD according to Mesulam's criteria OR Vascular Dementia according to NINDS-AIREN International Workshop AND Date of diagnosis not more than five years prior to consent Subjects must have MMSE scores of 23-30 (inclusive); or TICS40 score of 20-40 (inclusive) based on a test not older than 1 month at the time of consent. Age of 50-85 years (inclusive) | ||
| Group 2: Motor disorders | Parkinson's Disease (PD)
Motor neuron Disease (MND)
| ||
| Group 3: Affective disorders | Major Depressive Disorder (MDD)
Bipolar Disorder (BD)
Age of 18-85 years (inclusive). |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| The average length of speech elicitation for each speech task (in seconds) during the first week of self-assessments. | One week |
| Measure | Description | Time Frame |
|---|---|---|
| The intra-subject variance of length of speech elicitation for each speech task during the first week of self-assessments, as measured by Coefficients of Individual Agreement (CIA). | One week | |
| The inter-subject variance of length of speech elicitation for each speech task during the first week of self-assessments, as measured by Coefficients of Individual Agreement (CIA). |
Not provided
Inclusion Criteria:
macOS X with macOS 10.9 or later; OR Windows 7 or above; AND (2) Capable of audio recording; AND (3) Able to connect to the internet; AND (4) Have access to one of following internet browser software: Internet Explorer version 11 or above; OR Microsoft Edge version 12 or above; OR Firefox version 27 or above; OR Google Chrome version 30 or above; OR Safari version 7 or above.
Exclusion Criteria:
Not provided
Not provided
Study population is UK-based.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Allan Young, Professor | King's College London | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| South London and Maudsley NHS Foundation Trust | London | Greater London | SE5 8AZ | United Kingdom | ||
| King's College Hospital NHS Foundation Trust |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35667724 | Derived | Hampsey E, Meszaros M, Skirrow C, Strawbridge R, Taylor RH, Chok L, Aarsland D, Al-Chalabi A, Chaudhuri R, Weston J, Fristed E, Podlewska A, Awogbemila O, Young AH. Protocol for Rhapsody: a longitudinal observational study examining the feasibility of speech phenotyping for remote assessment of neurodegenerative and psychiatric disorders. BMJ Open. 2022 Jun 6;12(6):e061193. doi: 10.1136/bmjopen-2022-061193. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Group 4: Unaffected Controls | Group 4 specific recruitment criteria matched for the 'Group 1: Cognitive Disorders' cohort:
Group 4 specific recruitment criteria matched for the 'Group 2: Motor Disorders' cohort:
Group 4 specific recruitment criteria matched for the 'Group 3: Affective Disorders' cohort:
|
| One week |
| The subject average fraction of days during the first week of remote, self-assessment, where participants submitted at least one task response. | One week |
| The average length of speech elicitation for each speech task, during the telemedicine video conference. | baseline |
| The AUC of the binary classifier distinguishing between the AD diagnostic groups vs the applicable control group. | One month |
| The AUC of the binary classifier distinguishing between the Dementia with Lewy Bodies (LBD) diagnostic groups vs the applicable control group. | One month |
| The AUC of the binary classifier distinguishing between the PD diagnostic groups vs the applicable control group. | One month |
| The AUC of the binary classifier distinguishing between the MND diagnostic groups vs the applicable control group. | One month |
| The AUC of the binary classifier distinguishing between the Frontotemporal Dementia and Vascular Dementia (FTD/VCI) diagnostic groups vs the applicable control group. | One month |
| The AUC of the binary classifier distinguishing between the MDD diagnostic groups vs the applicable control group. | One month |
| The AUC of the binary classifier distinguishing between the BD diagnostic groups vs the applicable control group. | One month |
| The sensitivity of the binary classifier distinguishing between the AD diagnostic groups vs the applicable control group. | One month |
| The sensitivity of the binary classifier distinguishing between the LBD diagnostic groups vs the applicable control group. | One month |
| The sensitivity of the binary classifier distinguishing between the PD diagnostic groups vs the applicable control group. | One month |
| The sensitivity of the binary classifier distinguishing between the MND diagnostic groups vs the applicable control group. | One month |
| The sensitivity of the binary classifier distinguishing between the FTD/VCI diagnostic groups vs the applicable control group. | One month |
| The sensitivity of the binary classifier distinguishing between the MDD diagnostic groups vs the applicable control group. | One month |
| The sensitivity of the binary classifier distinguishing between the BD diagnostic groups vs the applicable control group. | One month |
| The specificity of the binary classifier distinguishing between the AD diagnostic groups vs the applicable control group. | One month |
| The specificity of the binary classifier distinguishing between the LBD diagnostic groups vs the applicable control group. | One month |
| The specificity of the binary classifier distinguishing between the PD diagnostic groups vs the applicable control group. | One month |
| The specificity of the binary classifier distinguishing between the MND diagnostic groups vs the applicable control group. | One month |
| The specificity of the binary classifier distinguishing between the FTD/VCI diagnostic groups vs the applicable control group. | One month |
| The specificity of the binary classifier distinguishing between the MDD diagnostic groups vs the applicable control group. | One month |
| The specificity of the binary classifier distinguishing between the BD diagnostic groups vs the applicable control group. | One month |
| The Cohen's kappa of the binary classifier distinguishing between the AD diagnostic groups vs the applicable control group. | One month |
| The Cohen's kappa of the binary classifier distinguishing between the LBD diagnostic groups vs the applicable control group. | One month |
| The Cohen's kappa of the binary classifier distinguishing between the PD diagnostic groups vs the applicable control group. | One month |
| The Cohen's kappa of the binary classifier distinguishing between the FTD/VCI diagnostic groups vs the applicable control group. | One month |
| The Cohen's kappa of the binary classifier distinguishing between the MDD diagnostic groups vs the applicable control group. | One month |
| The Cohen's kappa of the binary classifier distinguishing between the BD diagnostic groups vs the applicable control group. | One month |
| The AUC of the binary classifier distinguishing between the following diagnostic groups vs all other diagnostic groups (pooled): AD, LBD, PD, MND, FTD/VCI, MDD, BD. | One month |
| The sensitivity of the binary classifier distinguishing between the following diagnostic groups vs the other groups (pooled): AD, LBD, PD, MND, FTD/VCI, MDD, BD. | One month |
| The specificity of the binary classifier distinguishing between the following diagnostic groups vs the other groups (pooled): AD, LBD, PD, MND, FTD/VCI, MDD, BD. | One month |
| The Cohen's kappa of the binary classifier distinguishing between the following diagnostic groups vs the other groups (pooled): AD, LBD, PD, MND, FTD/VCI, MDD, BD. | One month |
| For each classifier/regressor in the outcomes, the correlation between the AUC/CIA and each age group, gender and speech-to-reverberation modulation energy ratio group, as measured by the Kendall rank correlation coefficient. | One month |
| London |
| Greater London |
| SE5 9RS |
| United Kingdom |
| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| D060825 | Cognitive Dysfunction |
| D020961 | Lewy Body Disease |
| D015140 | Dementia, Vascular |
| D057180 | Frontotemporal Dementia |
| D018888 | Aphasia, Primary Progressive |
| D010300 | Parkinson Disease |
| D016472 | Motor Neuron Disease |
| D003865 | Depressive Disorder, Major |
| D001714 | Bipolar Disorder |
| D000690 | Amyotrophic Lateral Sclerosis |
| D013060 | Speech |
| D007802 | Language |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D003072 | Cognition Disorders |
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D002561 | Cerebrovascular Disorders |
| D002537 | Intracranial Arteriosclerosis |
| D020765 | Intracranial Arterial Diseases |
| D056784 | Leukoencephalopathies |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D057174 | Frontotemporal Lobar Degeneration |
| D057177 | TDP-43 Proteinopathies |
| D057165 | Proteostasis Deficiencies |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D001037 | Aphasia |
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009468 | Neuromuscular Diseases |
| D003866 | Depressive Disorder |
| D019964 | Mood Disorders |
| D000068105 | Bipolar and Related Disorders |
| D013118 | Spinal Cord Diseases |
| D014705 | Verbal Behavior |
| D003142 | Communication |
| D001519 | Behavior |
Not provided
Not provided