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Language is an essential part of daily life, enabling us to communicate, understand others, read, and learn. Certain brain injuries can disrupt these abilities, and current treatments do not always lead to a full recovery. To improve future therapeutic approaches, it is necessary to better understand how the brain processes language and how its activity can be modulated.
This study aims to evaluate the effects of a non-invasive brain stimulation technique called transcranial random noise stimulation. This method involves applying a very weak electrical current to the scalp to modulate the activity of brain regions involved in language. It is commonly used in research and is considered safe when administered in accordance with current guidelines.
Healthy adult volunteers will participate in this study. Each participant will take part in two sessions spaced about a week apart. During one session, active stimulation will be used, and during the other, placebo stimulation will be used. Placebo stimulation resembles the actual stimulation but has no active effect. Neither the participants nor the researchers will know which type of stimulation is being used during each session.
During the sessions, participants will perform various language tasks, and their brain activity will be recorded using an electroencephalogram (EEG), a painless method.
This study does not provide any direct benefit to participants. The risks are low and limited to temporary sensations, such as a tingling sensation on the scalp. The results will provide a better understanding of how the brain processes language and could eventually contribute to the development of new rehabilitation approaches.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Younger adults | Other | age 15-35 years |
|
| Elderly adults | Other | age 60-90 years |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial random noise stimulation | Device | active HD-tRNS |
|
| Measure | Description | Time Frame |
|---|---|---|
| Composite score | composite behavioural score reflecting overall language performance across four language domains (phonological, semantic, morphosyntactic, and reading) | Periprocedural |
| Measure | Description | Time Frame |
|---|---|---|
| Phonological processing | pseudoword reading task: accuracy (% correct) and response latency (ms) | Periprocedural |
| Semantic processing | semantic fluency task: number of correct words produced within 1 min |
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Inclusion Criteria:
Exclusion Criteria:
History of neurological or psychiatric disease
Regular consumption of benzodiazepines, neuroleptics, or psychoactive drugs
Major language deficit, developmental language disorder, arthropathies and other mechanical language impairments
Inability to understand or follow study procedures
Contraindications to brain stimulation, such as
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Adrian Guggisberg, MD | Contact | +41223723700 | adrian.guggisberg@hug.ch |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Division of Neurorehabilitation, University Hospital of Geneva | Recruiting | Geneva | Canton of Geneva | 1211 | Switzerland |
EEG and behavioral data
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After publication
Depository
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| ID | Term |
|---|---|
| D007802 | Language |
| ID | Term |
|---|---|
| D003142 | Communication |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| sham stimulation | Device | current will be ramped up for 30 seconds and then switched of, to mimic the subjective sensation of tRNS. |
|
| Periprocedural |
| Morphosyntactic processing | grammaticality judgment task: accuracy (% correct) and response latency (ms) | Periprocedural |
| Reading speed | International reading speed test IReST: Reading time (s), words per minute, and error count | Periprocedural |
| Sustained attention | d2-R: standard concentration performance score and error rate (control measure) | Periprocedural |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |