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| ID | Type | Description | Link |
|---|---|---|---|
| R21DC021763 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Deafness and Other Communication Disorders (NIDCD) | NIH |
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The goal of this clinical trial is to learn if non-invasive brain stimulation (called transcranial stimulation) can enhance the benefits from auditory training in people who struggle to understand one talker when many people are talking at the same time. The main questions it aims to answer are:
Researchers will compare transcranial stimulation to sham stimulation (no stimulation is applied during the listening task).
Participants will:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active transcranial stimulation | Experimental | This group will receive active transcranial alternating current stimulation that matches the envelope of the target speech. |
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| Sham stimulation | Sham Comparator | This group will receive transcranial stimulation that ramps on and off before the speech is presented. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial current stimulation | Device | The transcranial alternating current stimulation is delivered during the speech stimulus and the current matches the envelope of the target speech |
| Measure | Description | Time Frame |
|---|---|---|
| Speech-on-speech intelligibility percent correct | Percent correct score on the speech-on-speech task assessed in the lab | From enrollment to the end of participation at 6 weeks |
| Pupillometry measured listening effort | The peak pupil dilation subtracted from pre-trial baseline pupil dilation, averaged across trials in a block, assessed in the lab | From enrollment to the end of participation at 6 weeks |
| QuickSIN SNR Loss | A speech-in-noise test assessed as part of the at-home auditory training program | Days 1, 6, and 14 of the two-week auditory training |
| Hearing Handicap Inventory | A listening effort questionnaire given as part of the at-home auditory training program | Days 1 and 14 of the two-week auditory training program |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Elin Roverud, AuD, PhD | Contact | 617-358-7440 | erover@bu.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Communication Neuroscience Research Lab at Boston University | Boston | Massachusetts | 02215 | United States |
The complete archive of all de-identified (anonymized) experimental data will be made available via Boston University's institutional archive repository "OpenBU". This will include individual participant scores on tasks and pupil dilation data. The data will be labeled with a unique study ID.
This data will be available no later than the end of the grant performance period (9/2026) and will be available indefinitely.
This data will be accessible to anyone via the stable URL link managed by the BU library.
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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Participants are randomly assigned to active transcranial stimulation or sham stimulation groups.
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| Auditory training | Behavioral | An at-home auditory training program that adaptively and interactively trains the listener in degraded speech, cognitive skills, and communication strategies |
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| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |