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ClinicalTrials.gov ID

NCT07546994

Lead Sponsor

Centre Hospitalier Universitaire de NīmesOTHER

Overall Status

Not yet recruiting

Study Type

Observational

Enrollment

150Estimated

Last Update Posted

Apr 23, 2026Actual

Start Date

Apr 2026Estimated

Primary Completion Date

Apr 2028Estimated

Completion Date

Apr 2028Estimated

Official Title

Biofilm-induced Antimicrobial Resistance RIsk ERadication in Critical Care Central Venous Catheters

Brief Summary

Central venous catheter (CVC) infections are a frequent and serious nosocomial complication in critical care, leading to increased morbidity, mortality, and costs. The pathophysiology of these infections relies on the formation of a biofilm, an organized microbial structure that confers exceptional tolerance to anti-infectives and the immune system. However, data concerning the characteristics of the in vivo biofilm (kinetics, composition, endo- vs. extraluminal organization) on central venous catheters in intensive care patients are very limited, hindering the development of effective and targeted prevention strategies.

The main aim of this study is to quantify the density and describe the spatial distribution (extra- and intraluminal compartments) of the biofilm on infected or colonized central venous catheters, prospectively collected from patients in the critical care units.

• Catheter-Related Infections
• Biofilms
• Infection Prevention

• Microbial analysis of catheter biofilm

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

• Central venous catheters (conventional central venous lines, dialysis catheters, PICC lines) showing positive microbiological culture taken from adult patients in the critical care units (intensive care units, post-operative intensive care units and post-resuscitation intensive care units)
• Patient consent is free, informed, and non-opposition, provided after delivery of an information letter and oral explanation.

Exclusion Criteria:

• None

Observational Model

Cohort

Time Perspective

Prospective

Lead Sponsor

Centre Hospitalier Universitaire de NīmesOTHER

drc@chu-nimes.fr04.66.68.42.36