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| Name | Class |
|---|---|
| Centre Hospitalier Universitaire Dijon | OTHER |
| Centre Hospitalier Macon | OTHER |
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29.3% of bacteremias in intensive care units (ICU) are linked to vascular devices, including 7.7% to arterial catheters, with an influence on both morbility and mortality.
It is now accepted that biofilm as a role on bacterial development on inner surface of vascular devices but there is yet a lack of clinical relevant data documenting a causal relation between biofilm formation and bacteremias.
The investigators assume that a better structural and microbiological characterization of arterial catheter biofilm in ICU patients could help preventing bacteremias or have a more specific treatment when it appears.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| OCT-BIO-KTA cohort | Critically ill patient > 18 years of age with artherial catheter for >2 calendar days in ICU |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| OCT-BIO-KTA cohort | Other | Dynamic full-field optical coherence tomography (D-FF-OCT) analysis of arterial catheter sections before microbiological analysis of catheter biofilm |
|
| Measure | Description | Time Frame |
|---|---|---|
| Biofilm structure type (ribbon-shaped or mushroom-shaped), measured with D-FF-OCT | Provide a better understanding of the relation between structural and microbiological characterization of artherial catheter biofilm in ICU patients using D-FF-OCT | Outcome measure is assessed 2 days following catheter removal |
| Measure | Description | Time Frame |
|---|---|---|
| Bacterial or fungal indentification | Identification and enumeration of species - whether bacterial or fungal - by mass spectrometry from culture in agar medium of biofilm samples | Outcome measure is assessed 2 days following catheter removal |
| Biofilm thickness, measured with D-FF-OCT |
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Inclusion Criteria:
Exclusion Criteria:
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Patient over 18 years of age with artherial catheter more than 2 calendar days
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Florian PERRAUD | Contact | 06 78 58 85 19 | florian.perraud@ch-chalon.fr | |
| Thomas MALDINEY | Contact | thomas.maldiney@ch-chalon.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Dijon Bourgogne | Recruiting | Dijon | Bourgogne-Franche-Comté | 21000 | France |
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Provide a better understanding of the relation between thickness and microbiological characterization of artherial catheter biofilm in ICU patients using D-FF-OCT |
| Outcome measure is assessed 2 days following catheter removal |
| Biofilm dynamic signal distribution, measured with D-FF-OCT | Provide a better understanding of the relation between dynamic signal distribution and microbiological characterization of artherial catheter biofilm in ICU patients using D-FF-OCT | Outcome measure is assessed 2 days following catheter removal |
| CH Macon | Recruiting | Mâcon | Bourgogne-Franche-Comté | 71000 | France |
|
| ID | Term |
|---|---|
| D016470 | Bacteremia |
| ID | Term |
|---|---|
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D018805 | Sepsis |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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