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| Name | Class |
|---|---|
| Saudi Food and Drug Authority | OTHER_GOV |
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This randomized crossover study aims to investigate the effect of circadian timing of a standardized meal (morning versus evening consumption) on postprandial glucose response in healthy adults. Postprandial glucose will be assessed using the incremental area under the curve (iAUC) over 120 minutes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Morning Meal Condition | Experimental | Participants will consume a standardized test meal in the morning following an overnight fasting period of at least 8 hours. Postprandial glucose will be measured over 120 minutes. |
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| Evening Meal Condition | Experimental | Participants will consume the same standardized test meal in the evening following a standardized fasting period of at least 8 hours prior to the test meal. Postprandial glucose will be measured over 120 minutes. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standardized Test Meal | Other | The standardized test meal provided 50 g of carbohydrates of weighed portions of white bread and jam, served with 200 mL of water. |
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| Measure | Description | Time Frame |
|---|---|---|
| Incremental Area Under the Curve (iAUC) for Postprandial Glucose | The primary objective of this study is to investigate the effect of circadian timing of a standardized test meal (morning versus evening consumption) on postprandial glucose response in healthy adults, assessed as the incremental area under the curve (iAUC) for capillary blood glucose over 120 minutes following meal consumption | Baseline to 120 minutes after consumption of the standardized test meal |
| Measure | Description | Time Frame |
|---|---|---|
| Peak Postprandial Glucose (Morning vs Evening) | Peak capillary blood glucose concentration measured within 120 minutes after consumption of the standardized test meal, under morning and evening conditions | Baseline to 120 minutes after consumption of the standardized test meal |
| Time to Peak Glucose (Morning vs Evening) |
| Measure | Description | Time Frame |
|---|---|---|
| Night Eating Behavior | Night eating behavior will be assessed using the validated Night Eating Questionnaire to characterize nocturnal eating patterns and support interpretation of variability in postprandial glucose responses. | Baseline |
| Sleep Duration and Quality |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wafa Alotaibi, PhD | Contact | +966500358622 | Walotaibi@kfu.edu.sa |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| King Faisal University | Al-Ahsa | Eastern Province | 31982 | Saudi Arabia |
De-identified individual participant data (IPD) collected in this study will not be made publicly available. Data will be used for research purposes by the study investigators only
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Time required to reach peak capillary blood glucose concentration following meal consumption, under morning and evening conditions. |
| Baseline to 120 minutes after consumption of the standardized test meal |
| Postprandial Glucose Profile (Morning vs Evening) | Capillary blood glucose concentrations measured at predefined time points following consumption of the standardized test meal, under morning and evening conditions. | Baseline, 15, 30, 60, 90, and 120 minutes after consumption of the standardized test meal |
Sleep duration and quality will be assessed using a validated sleep questionnaire administered prior to each study visit to support interpretation of postprandial glucose responses. |
| Baseline |
| Chronotype | Chronotype will be assessed at baseline using the validated Questionnaire to characterize individual circadian preference and support interpretation of postprandial glucose responses. | Baseline |