Effectiveness of Serratiopeptidase After Mandibular Third Molar Surgery

Efficacy of Serratiopeptidase After Surgical Removal of Mesioangular Mandibular Third Molars: A Randomized Controlled Trial

This randomized controlled trial was conducted to compare the effect of serratiopeptidase versus no intervention on postoperative mouth opening, swelling, and trismus following surgical removal of mesioangular mandibular third molars.

A total of 110 patients undergoing surgical extraction of mesioangular mandibular third molars were randomly assigned into two groups. Group A received serratiopeptidase postoperatively, while Group B received no enzyme therapy. Mouth opening was measured postoperatively and compared between the two groups to assess the effectiveness of serratiopeptidase in reducing trismus and postoperative swelling.

Inclusion Criteria:

- Patients aged 18 to 40 years.

Patients requiring surgical removal of a mesioangular impacted mandibular third molar.

Patients who are systemically healthy (ASA I or II).

Patients willing to participate and provide written informed consent.

Patients who can comply with postoperative follow-up visits.

Exclusion Criteria:

• Patients with systemic diseases affecting healing (e.g., diabetes, immunocompromised state).

Pregnant or lactating women.

Patients with known allergy or hypersensitivity to serratiopeptidase.

Patients on long-term anti-inflammatory or steroid medication.

Presence of acute infection at the surgical site.

Patients who have taken anti-inflammatory drugs within 48 hours before surgery.