This randomized controlled trial was conducted to compare the effect of serratiopeptidase versus no intervention on postoperative mouth opening, swelling, and trismus following surgical removal of mesioangular mandibular third molars.

A total of 110 patients undergoing surgical extraction of mesioangular mandibular third molars were randomly assigned into two groups. Group A received serratiopeptidase postoperatively, while Group B received no enzyme therapy. Mouth opening was measured postoperatively and compared between the two groups to assess the effectiveness of serratiopeptidase in reducing trismus and postoperative swelling.

Inclusion Criteria:

- Patients aged 18 to 40 years.

Patients requiring surgical removal of a mesioangular impacted mandibular third molar.

Patients who are systemically healthy (ASA I or II).

Patients willing to participate and provide written informed consent.

Patients who can comply with postoperative follow-up visits.

Exclusion Criteria:

• Patients with systemic diseases affecting healing (e.g., diabetes, immunocompromised state).

Pregnant or lactating women.

Patients with known allergy or hypersensitivity to serratiopeptidase.

Patients on long-term anti-inflammatory or steroid medication.

Presence of acute infection at the surgical site.

Patients who have taken anti-inflammatory drugs within 48 hours before surgery.